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Regulation of organelle-selective autophagy by ubiquitin E3 ligases
Organelle-selective autophagy (OSA) is emerging as a critical and highly coordinated cellular process and its dysfunction is linked to cancer and neurological diseases. Crucially, OSA requires the timely ubiquitination of substrates, yet the E3 ligases involved and how their activity is regulated are poorly understood. Our lab has pioneered the development of activity-based probes for ~350 E3 ligases, and this project will deploy them on a proteome-scale to detect changes in E3 activity upon OSA (Pao et al., Nat Chem Biol 2016; Pao et al. Nature 2018; Mathur et al. Cell Chem Biol 2020). The role of E3 ligases in will be validated and their regulatory mechanism delineated. For informal enquiries please contact Prof. Satpal Virdee s.s.virdee@dundee.ac.uk.
Passionate candidates should ideally have recently carried out a PhD working in cell biology or biochemistry. The position will be a fantastic opportunity for candidates to broaden their skillset by working in a multidisciplinary lab using state-of-the-art technologies. Coupled with this exciting area of biological focus, the project will provide excellent opportunity for career development with mentoring support to reach career aspirations. The successful applicants will join an international team in an exciting and interactive environment, equipped to the very highest standards, and with generous consumable support.
Your priorities will include:
- Plan and carry out multidisciplinary research program aimed at identifying E3 ligases regulating organelle selective autophagy
- Presentation of research at lab meetings and scientific meetings
- Preparation of data for manuscript preparation
- Liaise with other lab members and collaborators
- Maintenance of meticulous lab records
Who we're looking for:
Passionate candidates should ideally have recently carried out a PhD working in the biochemistry, structural biology or cell biology.
- A passion for ubiquitin biology
- Experience in cell biology or biochemistry
This contract is for a fixed term period of 3 years with the possibility for extension.
To apply on-line please visit: www.dundee.ac.uk/jobs. If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number
The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment. We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.
The University of Dundee has received the Athena SWAN Bronze Award which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.
The University of Dundee is a Scottish Registered Charity, No. SC015096.