Publications (2012)
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(835 publications archived)


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Appleyard, M. V., Murray, K. E., Coates, P. J., Wullschleger, S., Bray, S. E., Kernohan, N. M., Fleming, S., Alessi, D. R. and Thompson, A. M. (2012). Phenformin as prophylaxis and therapy in breast cancer xenografts. Br J Cancer 106, pp. 1117-1122 pubmed
Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, K., Hue, L. and Rider, M. H. (2012). AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase. Biochem J 443, pp. 193-203 pubmed
Goh, E. T., Arthur, J. S., Cheung, P. C., Akira, S., Toth, R. and Cohen, P. (2012). Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system. Biochem J 441, pp. 339-346 pubmed
Ho, K. K., McGuire, V. A., Koo, C. Y., Muir, K. W., de Olano, N., Maifoshie, E., Kelly, D. J., McGovern, U. B., Monteiro, L. J., Gomes, A. R., Nebreda, A. R., Campbell, D. G., Arthur, J. S. and Lam, E. W. (2012). Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin. J Biol Chem 287, pp. 1545-1555 pubmed
Liu, Q., Kirubakaran, S., Hur, W., Niepel, M., Westover, K., Thoreen, C. C., Wang, J., Ni, J., Patricelli, M. P., Vogel, K., Riddle, S., Waller, D. L., Traynor, R., Sanda, T., Zhao, Z., Kang, S. A., Zhao, J., Look, A. T., Sorger, P. K., Sabatini, D. M. and Gray, N. S. (2012). Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics. J Biol Chem 287, pp. 9742-9752 pubmed
Naqvi, S., Macdonald, A., McCoy, C. E., Darragh, J., Reith, A. D. and Arthur, J. S. (2012). Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem J 441, pp. 347-357 pubmed
Pathak, S., Borodkin, V. S., Albarbarawi, O., Campbell, D. G., Ibrahim, A. and van Aalten, D. M. (2012). O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. Embo J 31, pp. 1394-1404 pubmed
Thastrup, J. O., Rafiqi, F. H., Vitari, A. C., Pozo-Guisado, E., Deak, M., Mehellou, Y. and Alessi, D. R. (2012). SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation. Biochem J 441, pp. 325-337 pubmed
Wullschleger, S., Garcia-Martinez, J. M. and Duce, S. L. (2012). Quantitative MRI Establishes the Efficacy of PI3K Inhibitor (GDC-0941) Multi-Treatments in PTEN-deficient Mice Lymphoma. Anticancer research 32, pp. 415-420 pubmed
Zhang, J., Deng, X., Choi, H. G., Alessi, D. R. and Gray, N. S. (2012). Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorg Med Chem Lett 22, pp. 1864-1869 pubmed
Zhang, T., Inesta-Vaquera, F., Niepel, M., Zhang, J., Ficarro, S. B., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T., Laughlin, J. D., Park, H., Lograsso, P. V., Patricelli, M., Nomanbhoy, T. K., Sorger, P. K., Alessi, D. R. and Gray, N. S. (2012). Discovery of Potent and Selective Covalent Inhibitors of JNK. Chem Biol 19, pp. 140-154 pubmed
Alers, S., Loffler, A. S., Paasch, F., Dieterle, A. M., Keppeler, H., Lauber, K., Campbell, D. G., Fehrenbacher, B., Schaller, M., Wesselborg, S. and Stork, B. (2011). Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction. Autophagy 7, pp. 1424-1433 pubmed
Banko, M. R., Allen, J. J., Schaffer, B. E., Wilker, E. W., Tsou, P., White, J. L., Villen, J., Wang, B., Kim, S. R., Sakamoto, K., Gygi, S. P., Cantley, L. C., Yaffe, M. B., Shokat, K. M. and Brunet, A. (2011). Chemical Genetic Screen for AMPKalpha2 Substrates Uncovers a Network of Proteins Involved in Mitosis. Mol Cell 44, pp. 878-892 pubmed
Bertelsen, T., Iversen, L., Riis, J. L., Arthur, J. S., Bibby, B. M., Kragballe, K. and Johansen, C. (2011). The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice. Exp Dermatol 20, pp. 140-145 pubmed
Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. and Alessi, D. R. (2011). TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Biochem J 437, pp. 157-167 pubmed
Cerezo-Guisado, M. I., Reino, P. D., Remy, G., Kuma, Y., Arthur, J. S., Gallego-Ortega, D. and Cuenda, A. (2011). Evidence of p38{gamma} and p38{delta} involvement in cell transformation processes. Carcinogenesis 32, pp. 1093-1099 pubmed
Chang, S., Iversen, L., Kragballe, K., Arthur, J. S. and Johansen, C. (2011). Mice Lacking MSK1 and MSK2 Show Reduced Skin Tumor Development in a Two-Stage Chemical Carcinogenesis Model. Cancer Invest 29, pp. 240-245 pubmed
Chen, S., Synowsky, S., Tinti, M. and Mackintosh, C. (2011). The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin. Trends Endocrinol Metab 22, pp. 429-436 pubmed
Chen, S., Wasserman, D. H., Mackintosh, C. and Sakamoto, K. (2011). Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking. Cell Metab 13, pp. 68-79 pubmed
Chiga, M., Rafiqi, F. H., Alessi, D. R., Sohara, E., Ohta, A., Rai, T., Sasaki, S. and Uchida, S. (2011). Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. J Cell Sci 124, pp. 1391-1395 pubmed