Increasing evidence shows that alterations and mutations in the UPS give rise to various human diseases, such as cancer and neurodegenerative disorders. Our interest is to understand how the activity of the ubiquitin-proteasome system is regulated in cells so that accumulation of unfolded, misfolded, or damaged proteins can be cleared before they become deleterious. We recently reported that proteasomal degradation is regulated upon proteotoxic stresses in a phosphorylation-dependent manner (Rousseau and Bertolotti, 2016). The new project will focus on how protein phosphorylation events regulate protein homeostasis and cell survival. Using global phosphoproteomics, we have recently identified various potential substrates of Mpk1 kinase which are selectively phosphorylated upon stress. The project will consist in characterising the importance of these phosphorylation events in the regulation of protein homeostasis and cell survival. In addition, we are interested to identify post-translational modification regulating the function of the 26S proteasome. Both yeast and mammalian systems will be used for this project.
At the MRC PPU, as well as the possibility of a PhD in one particular lab, we offer the possibility of two 4.5-month rotations in labs of their choice. A range of other projects from MRC PPU scientists are advertised on this website. Rotations provide valuable experience and help with deciding on the choice of PhD project and research group.
Please send a CV with contact details of three referees to and a cover letter, explaining why you have chosen to apply to MRC PPU, to firstname.lastname@example.org. The closing date for applications is 15th November 2021. We will chat with long-listed applicants by Zoom in November/December 2021 to select candidates to take forward. Interviews will take place in January 2022. Applications from overseas students are welcome.