Studentship | How does the TRAIP ubiquitin ligase guard the mammalian genome from damage?

MRC Funded
Project with

The TRAIP ubiquitin ligase is a key regulator of genome integrity in mammalian cells.  The importance of TRAIP is highlighted by the fact that mutation leads to a human disease syndrome, whilst over-expression of TRAIP can be associated with human cancer.  Recent work has indicated that TRAIP associates with the replisome and ubiquitylates potential barriers in front of DNA replication forks, to activate DNA repair pathways.  In addition, TRAIP is regulated during mitosis to destroy any remaining replisomes and allow for rapid processing of replication forks to facilitate chromosome segregation.  It is likely that TRAIP has additional important targets that remain to be identified.  This project will use a combination of cutting edge biochemical and molecular genetic techniques to identify and characterise novel targets of TRAIP, to explore their role in preserving genome integrity in mammalian cells.  As well as being an exciting project in a fascinating area of fundamental cell biology, such new targets of TRAIP are also likely to be important in the context of human disease.

Application Procedure

We are currently accepting applications for our 2023 programme. To apply, please send the following to mrcppu-phd-admin@dundee.ac.uk
 

  • Cover letter explaining your interest in our work. Please also indicate which group(s) you are most interested in, and whether you prefer rotations or would like to join one lab directly.
  • CV with contact details of three referees.


Applications from overseas students are welcome. The closing date for the first round of applications is January 31st 2022