Mission Statement

This is an exhilarating time in phosphorylation and ubiquitylation research. The MRC Protein Phosphorylation and Ubiquitylation Unit (PPU) is  a major research centre that focuses on the understanding of the biological roles of  phosphorylation and ubiquitylation  and how disruption of these processes cause human diseases such as neurodegeneration, cancer, hypertension and immune disorders. The ultimate goal of the Unit’s research programmes is to help develop new improved strategies to treat disease.

The MRC-PPU operates as a focal point between life scientists, pharmaceutical companies and clinicians to ensure that we make a critical contribution to medical research, together reaching a deeper understanding of disease.

Our unit provides an exciting research environment and our staff with a unique research and training experience. Our researchers’ makes use of cutting-edge technology and biochemistry to study cellular regulation and molecular mechanisms across a number of diseases. Our PIs' research programmes tackle major long-term challenges in cell signalling and disease. We seek to train the next generation of PhD students and Postdocs maximising their potential to make major contributions to scientific progress and drug discovery.

Another important feature of our Unit is the large number of collaborations between our PI's, enabling us to addressing challenging problems that contribute to the overall strength of our Unit being much greater than the sum of the individual parts. A key aim of our Unit is to also boost interactions with clinicians and to attract more clinical PhD students and researchers to our laboratories. This will help ensure our research addresses the most critical clinically relevant questions.