Kulathu Lab

Welcome to the Kulathu Lab!

We are part of the MRC Protein Phosphorylation & Ubiquitylation Unit at the University of Dundee.

Research in the lab is focussed on discovering  the fundamental principles of how cellular homeostasis is maintained by the ubiquitin system. Almost every cellular process in eukaryotes is regulated by the posttranslational modification of proteins with ubiquitin. In our research we use a multidisciplinary approach with techniques ranging from biochemistry, structural biology and proteomics to studies in model organisms to gain mechanistic and functional insights into ubiquitin signalling mechanisms in health and disease.

The two main biological questions we address are:

1. How is protein homeostasis maintained by the ubiquitin system?

2. How are T lymphocyte biology and adaptive immune responses regulated by ubiquitin signalling networks?

Find out more about our research here