Kulathu Lab
Publications
Leznicki P, Natarajan J, Bader G, Spevak W, Schlattl A, Rehman SAA, Pathak D, Weidlich S, Zoephel A, Bordone MC, Barbosa-Morais NL, Boehmelt G, Kulathu Y. (2018) “Expansion of DUB functionality by alternative isoforms: USP35, a case study”. J Cell Sci. 131(10).
Kwasna D, Abdul-Rehman SA, Natarajan J, Madden R, Matthews S, Weidlich S, Ahel I, Seymour IG, Kulathu Y. (2018) “Discovery and characterization of ZUFSP, a novel DUB class important for genome stability”. Molecular Cell. 70(1):150-164.
Leznicki P, Kulathu Y. (2017) “Mechanisms of regulation and diversification of deubiquitylating enzyme function”. J Cell Sci. 130(12):1997-2006.
Hall EA, et al. (2017) PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. Am J Hum Genet. 100(5):706-724
Kristariyanto YA, Abdul-Rehman SA, Weidlich S, Knebel A, Kulathu Y. (2017) "A single MIU motif of MINDY‐1 recognizes K48‐linked polyubiquitin chains". EMBO Reports 18 (3): 392-402
Abdul-Rehman SA, Kristariyanto YA, Choi SY, Nkosi P, Labib K, Hofmann K & Kulathu Y. (2016) “MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of Deubiquitinating enzymes”. Molecular Cell 63(1):146-55 Abstract
Mevissen TE, Kulathu Y, et al. (2016) "Molecular basis of Lys11-polyubiquitin specificity in the
deubiquitinase Cezanne". Nature. 538(7625):402-405. Abstract
Huguenin-Dezot N, De Cesare V, Peltier J, Knebel A, Kristariyanto YA, Rogerson DT, Kulathu Y, Trost M, Chin JW. (2016) “Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity”. Cell Reports. 16(4):1180-93. Abstract
Kulathu Y (2016) “Novel Diubiquitin probes to expand the chemical toolkit to study DUBs”. Cell Chemical Biology 23: 432-434 Abstract
Kristariyanto YA, Abdul-Rehman SA, Campbell DG, Morrice NA, Toth R & Kulathu Y (2015) “K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin”. Molecular Cell 58(1): 83-94 Abstract
Kristariyanto YA, Choi SY, Abdul-Rehman SA, Ritorto S, Campbell DG, Morrice NA, Toth R & Kulathu Y (2015) “Assembly and structure of Lys33-linked chains reveals distinct conformations”. Biochem Journal 467(2): 345-52 Abstract
K29 chains in complex with NZF domain
DUB probes over the years
Mechanism of polyUb binding by MINDY-1 MIU
K29 chains and their recognition
MINDY on the cover of Mol Cell
Discovery of a new family of DUBs
Subcellular localization of DUBs (JCS review)
Isoform-specific functions for USP35
Discovery of ZUP1 as a novel class of DUBs
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