Kulathu Lab

 

Research goals

 

The Kulathu lab is focussed on understanding the mechanisms of signal transduction by ubiquitin and UBLs to maintain cellular homeostasis.

 

 We employ a multidisciplinary approach combining structural biology, biochemistry, proteomics and mouse models to address these major questions:

1. How is protein homeostasis maintained by the ubiquitin system?

2. How are T lymphocyte biology and adaptive immune responses regulated by ubiquitin and UBL networks?

 

We address these questions by tackling the nature of the ubiquitin signals, how ubiquitin binding proteins decode and integrate these signals and lastly how the functional outcomes of ubiquitylation are regulated by DUBs.

 

Find out more about the research in our lab:

 

Ubiquitin signalling: Nature of ubiquitin signals, complexity and decoding

 

DUBs - substrate targeting and biology

 

Regulation of protein degradation

 

T-lymphocyte activation and adaptive immune responses