Activity-based proteomic profiling of E3 ligases in disease-relevant signalling pathways

Applications are invited for a Postdoctoral Research Assistant in the lab of Dr Satpal Virdee to apply powerful probe technology that allows the direct measurement of E3 activity in cells (Nature Chemical Biology 2016, Nature 2018 in press). The project will involve the preparation of cellular samples which will be profiled for E3 ligase activity using procedures established in the Virdee lab. Samples will then be analysed by quantitative mass spectrometry. E3 ligases found to undergo distinct regulation will be further investigated by cell biological and biochemical approaches. Experience with mass spectrometry and the ubiquitin system would be highly desirable.

The successful applicant will join an international team in an exciting and interactive environment, equipped to the highest international standards. For further details, please consult http://www.ppu.mrc.ac.uk

Candidate requirements:

- PhD, with outstanding academic track record and at least one first authored publication (or on track to publish) in an internationally recognized journal.
- Enthisiasm for multidisciplinary science
- Capable of working in a team, but able to plan and work independently.
- Excellent communication skills and knowledge of the English language.

This contract is for a fixed term period of 3 years with the possibility of extension.

The appointment will be made on the Grade 7 salary scale plus superannuation with initial placement depending on achievements and experience, but will be up to £34,520 (Spinal Point 32).

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £30,688).

MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):

This project will be performed in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the School of Life Sciences at the University of Dundee. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the School of Life Sciences at the University of Dundee which is one of the premier Life Sciences research centres in the world.

How to apply:

To apply on-line please visit: https://www.dundee.ac.uk/jobs

The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment. We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.

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