News

Theresita Joseph, who was jointly supervised by Miratul Muqit and Dario Alessi, has successfully defended her Masters by Research Degree (MSc) studying Parkinson’s signalling pathways in human and mouse immune cells.

Theresita Joseph, who was jointly supervised by Miratul Muqit and Dario Alessi, has successfully defended her Masters by Research Degree (MSc) studying Parkinson’s signalling pathways in human and mouse immune cells.

Hannah Tovell, a PhD student in Dario Alessi's lab, working in collaboration with Claire Crafter (AstraZeneca) and Alessio Ciulli and Andrea Testa in the Ciulli lab, have elaborated a compound that we have termed SGK3-PROTAC1 that induces selective degradation of SGK3 protein kinase.

On 21st August, MRC PPU proteomic research manager, Dr. Houjiang Zhou, delivered a distinguished alumni lecturer in DICP, China. In honour of DCIP's many significant contributions to the field of analytic chemistry in the past 70 years, the lecture was awarded to Houjiang in recognition of his innovative PhD research in DICP on development of highly specific phosphopeptide enrichment technology and his pioneering role to establish research collaborations on proteomics between China and Canada. Houjiang delivered his latest collaborative research with Prof. Dario Alessi and Prof. …more

The concerted action of several protein kinases helps orchestrate the error-free transition through a mammalian cell division cycle. Although some prominent players such as cyclin-dependent kinases, polo-like kinases, and Aurora kinases have dominated the cell division limelight for decades, it is increasingly apparent that these kinase families alone cannot account for the extent of protein phosphorylation that has been reported during mammalian mitosis. Yet, the identity and precise roles of additional kinases during cell division cycle has remained undefined.

Kristin Balk, who has been undertaking research in Miratul Muqit’s lab funded by a J Macdonald Menzies Charitable Trust Prize Studentship, has successfully defended her PhD. During her studies Kristin has developed improved methods to study PINK1 signalling in cell lines and applied this to uncover a role for mitochondrial E3 ligases in the generation of Phospho-ubiquitin. Her examiners were Alex Whitworth of the MRC Mitochondrial Biology Unit in Cambridge and Gopal Sapkota of School of Life Sciences.

MRC PPU Reagents and Services are delighted to announce the official launch of our new custom sheep Polyclonal Antibody Production Service.

We have been producing antibodies for over 25 years and during this time period have raised in excess of 2500 different sheep polyclonal antibodies, which have been critical to the research publications generated by MRC PPU.

With the launch of this service we are now able to share our expertise with academics and pharmaceutical scientists from around the world.

Please visit our website to find out more - https://antibodies.mrc.ac.uk

Congratulation to Beatrice Filippi for being awarded a very prestigious MRC Career Development Fellowship (£1.4m) to support her research for the next 5 years to investigate how an area of the brain called Dorsal Vagal Complex (DVC) senses insulin and controls glucose metabolism and feeding behavior in animals.

About 10 years ago, the discovery of the Linear Ubiquitin Assembly Complex (LUBAC) revolutionized our understanding of how the master transcription factor NF-kB was activated.  LUBAC a complex of the three proteins, HOIP, HOIL-1 and Sharpin, produces unique “linear” ubiquitin chains in which ubiquitins are joined to each other by peptide bonds. …more