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Embryonic Stem Cell Signalling in Health and Disease
Our lab applies cutting-edge chemical, genetic, proteomic and transcriptomic technologies to investigate signalling mechanisms that regulate Embryonic Stem (ES) cell biology. Using these approaches, we have uncovered a series of exciting new ES cell signalling pathways, providing key insights into regulation of stem cell maintenance, pluripotency and differentiation. The current aim of this project is to identify the mechanisms by which these pathways function to control ES cell biology. Recently, we have begun exploring how disruptions to stem cell signalling networks lead to human developmental disorders, particularly intellectual disability. A major goal of this project is to pinpoint novel signalling components that are mutated in intellectual disability syndromes, and use stem cell models to elucidate the molecular mechanisms underpinning development of these disorders in patients.