The organization of our genomes into chromatin controls the degree of DNA accessibility, which in turn regulates which genes are expressed. This is essential to preserves the identity and stability of our cells. It is therefore not surprising that mutations in the proteins that make up chromatin are linked to human diseases such as cancer and neurodevelopmental disorders.

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‘Exchanges: Inspiring Parkinson’s Conversations’ project wins Stephen Fry Public Engagement Project of the Year Award …more

Researchers from Adrien Rousseau’s lab have identified how protein phase separation helps cell stress adaptation. This new study is now published in iScience.

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The MRC PPU are hugely proud that one of our Dundee Research Interest Group (DRIG) members, John Minhinick, has been awarded a British Empire Medal (BEM) in the New Year Honours List. This award recognises John’s considerable contribution to the Parkinson’s community in Fife and across Scotland. We thank John for all his work and wish him many congratulations on this achievement.

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Parkinson’s VPS35[D620N] mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B

We previously observed that the Parkinson’s VPS35[D620N] mutation markedly enhances LRRK2 kinase activation by an unknown mechanism.

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Tom Snelling (postdoc) and Anton Saalfrank (MSc student) in Philip Cohen’s lab have unveiled new insights into how mutations in the protein kinase ALPK1 cause two debilitating human diseases called ROSAH syndrome and Spiradenocarcinoma.

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Researchers from Adrien Rousseau’s lab in the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee, Scotland, have identified mechanisms contributing to the stress-induced reduction in protein translation using yeast. This new study is now published in EMBO Journal.

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When cells encounter a virus, they respond by upregulating the expression of hundreds of interferon-stimulated genes (ISGs). ISG15 is a ubiquitin-like protein that is highly upregulated in response to viral infection and has critical roles in the innate immune response.

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Dr Dina Dikovskaya, a senior research associate in the MRC PPU, has been awarded a Career Enhancing Grant by British Society for Immunology to conduct a pilot study on the importance of the oxidative stress response in Crohn’s disease.

This scheme offers flexible financial support to help BSI members at all career stages to benefit their careers.

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Dr Chiara Maniaci has been awarded £1.5 million to fund her research for the next eight years, from the highly esteemed University Research Fellowship from the

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