News

Mutations in the gene encoding the CDKL5 kinase are among the most common genetic causes of childhood epilepsy and can also give rise to the severe neurodevelopmental condition CDD (CDKL5 Deficiency Disorder). Despite its importance for human health, the phospho–targets and cellular roles of CDKL5 are poorly understood. Finding the cellular substrates of CDKL5 is critically important because the pathological mutations in CDKL5 reduce kinase activity to varying degrees,  implying that is a reduction in substrate phosphorylation that causes brain dysfunction and neurological disease. …more

We are delighted to announce that Kirby Swatek will open an independent research laboratory in the MRC PPU at the beginning of 2022.  He will take up a core funded MRC Investigator position to investigate the role played by the ubiquitin-like protein ISG15 in key immune responses that protect cells from invading viruses.

 

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Research from the MRC PPU has shed new light into how immune cells  tolerate the presence of harmless food and symbiotic bacteria in the gut, preventing needless immune responses and inflammation in the gut. The new study is published in eLife.

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MRC PPU researchers partnered with the Tropicalist Trust to run an event for school pupils in the upper reaches of the Himalayas, northern India to inspire them to consider a career in science.

The event took place online, with over 40 pupils attending from local high schools in the cold desert area of Kargil in the Himalayas. The remote location presented technology challenges, but after date and venue changes in order to find a reliable internet connection the event successfully took place on 6th September 2021.

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We are delighted to announce that Virginia has been awarded a UKRI Future Leaders Fellowship, one of the UK’s flagship fellowship schemes for early career investigators, in addition to being promoted to an independent Investigator position within the MRC-PPU.

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MRC-PPU Postdoctoral Researcher Francisco Bustos has been appointed Assistant Professor at Sanford Research, South Dakota USA

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Edmond (Eddy) Fischer, who discovered the first enzyme regulated by reversible protein phosphorylation, died on August 27th 2021. He was 101. His fundamental discovery, which led to the realization that this process controls most aspects of cell life, earned Eddy together with his colleague, friend and collaborator Edwin Krebs, the 1992 Nobel Prize for Physiology or Medicine.

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Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is characterised by the loss of midbrain dopaminergic neurons. The physiological and molecular mechanisms leading to this neuronal loss are currently unclear; however, mitochondrial and lysosomal dysfunction seem to play a central disease role. Mitophagy, the lysosomal turnover of mitochondria, is a quality control mechanism that links both these organelles and is used by cells to recycle old, damaged and dysfunctional mitochondria. A failure of this pathway is very detrimental to cell health. …more

In a new paper just published in The EMBO Journal, Yisui Xia, Ryo Fujisawa, Remi Sonneville & Tom Deegan from Karim Labib’s group in the MRC PPU have revealed the mechanism of replisome disassembly in animal cells, using the nematode Caenorhabditis elegans as a model system.

 

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Postdoctoral researchers from MRC PPU (University of Dundee) are pleased to be involved in organizing the 6th Scottish Biomedical Postdoctoral Researcher Conference, along with postdoctoral societies at the Institute of Genetics and Cancer (University of Edinburgh) and CRUK Beatson Institute (University of Glasgow).

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