The concerted action of several protein kinases helps orchestrate the error-free transition through a mammalian cell division cycle. Although some prominent players such as cyclin-dependent kinases, polo-like kinases, and Aurora kinases have dominated the cell division limelight for decades, it is increasingly apparent that these kinase families alone cannot account for the extent of protein phosphorylation that has been reported during mammalian mitosis. Yet, the identity and precise roles of additional kinases during cell division cycle has remained undefined.…more
Kristin Balk, who has been undertaking research in Miratul Muqit’s lab funded by a J Macdonald Menzies Charitable Trust Prize Studentship, has successfully defended her PhD. During her studies Kristin has developed improved methods to study PINK1 signalling in cell lines and applied this to uncover a role for mitochondrial E3 ligases in the generation of Phospho-ubiquitin. Her examiners were Alex Whitworth of the MRC Mitochondrial Biology Unit in Cambridge and Gopal Sapkota of School of Life Sciences.
MRC PPU Reagents and Services are delighted to announce the official launch of our new custom sheep Polyclonal Antibody Production Service.
We have been producing antibodies for over 25 years and during this time period have raised in excess of 2500 different sheep polyclonal antibodies, which have been critical to the research publications generated by MRC PPU.
With the launch of this service we are now able to share our expertise with academics and pharmaceutical scientists from around the world.
Please visit our website to find out more - https://antibodies.mrc.ac.uk…more
Congratulation to Beatrice Filippi for being awarded a very prestigious MRC Career Development Fellowship (£1.4m) to support her research for the next 5 years to investigate how an area of the brain called Dorsal Vagal Complex (DVC) senses insulin and controls glucose metabolism and feeding behavior in animals.
About 10 years ago, the discovery of the Linear Ubiquitin Assembly Complex (LUBAC) revolutionized our understanding of how the master transcription factor NF-kB was activated. LUBAC a complex of the three proteins, HOIP, HOIL-1 and Sharpin, produces unique “linear” ubiquitin chains in which ubiquitins are joined to each other by peptide bonds. …more
David Nicolls, a Principal Investigator at the University of Dundee from 1976 until 2000, has been elected a Fellow of the Royal Society (FRS) for the ground breaking research that he carried out at Dundee over this period.…more
How are nerve cells influenced by immune cells ? This was a central question addressed recently at a neuroimmunology workshop held at the School of Life Sciences in Dundee.
This approach makes use of CRISPR/Cas9 genome editing technology to introduce a Halo tag onto the N or C terminus of any desired target protein that can then be targeted for degradation by a HaloPROTAC probe (see Figure).…more
The 2nd Dundee Edinburgh Parkinson’s Research Initiative Public Event organized by Dr Esther Sammler at the Royal College of Physicians in Edinburgh on March 22, 2019 was a great success.
Highlight of the Public Event was the panel discussion hosted and chaired by John Minhinick, Fife Branch of Parkinson’s UK and committee member of the Dundee Parkinson's Research Interest Group, on eight themes important to people affected by Parkinson’s disease:
1. Why did I get Parkinson’s?…more