News

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is characterised by the loss of midbrain dopaminergic neurons. The physiological and molecular mechanisms leading to this neuronal loss are currently unclear; however, mitochondrial and lysosomal dysfunction seem to play a central disease role. Mitophagy, the lysosomal turnover of mitochondria, is a quality control mechanism that links both these organelles and is used by cells to recycle old, damaged and dysfunctional mitochondria. A failure of this pathway is very detrimental to cell health. …more

In a new paper just published in The EMBO Journal, Yisui Xia, Ryo Fujisawa, Remi Sonneville & Tom Deegan from Karim Labib’s group in the MRC PPU have revealed the mechanism of replisome disassembly in animal cells, using the nematode Caenorhabditis elegans as a model system.

 

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Postdoctoral researchers from MRC PPU (University of Dundee) are pleased to be involved in organizing the 6th Scottish Biomedical Postdoctoral Researcher Conference, along with postdoctoral societies at the Institute of Genetics and Cancer (University of Edinburgh) and CRUK Beatson Institute (University of Glasgow).

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Mahima Swamy lab in the MRCPPU, have identified a new potential drug target for coeliac disease that could relieve inflammation and unlock alternative treatment options.

Her lab has investigated how the cytokine IL-15 leads to activation of intestinal immune cells, and discovered the PIM kinases as potential new drug targets for Coeliac disease.

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Seven new papers have been published today in The Biochemical Journal, representing a major collaboration between multiple groups at the Francis Crick Institute in London, University College London and The University of Dundee.  Led by John Diffley at the Francis Crick Institute, with important contributions in Dundee from the groups of Yogesh Kulathu and Karim Labib in the MRC Protein Phosphorylation and Ubiquitylation Unit, together with  …more

Held annually by many universities worldwide, including the University of Dundee, the Three Minute Thesis (3MT) competition challenges doctoral candidates to present a compelling spoken presentation on their research topic and its significance in just three minutes to non-specialist audiences.

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Ayaz Najafov appointed Assistant Professor in UT Southwestern Medical Center in Dallas

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Published today in Acta Neuropathologica! New paper from the Sammler lab: 1-4% of the estimated 10 million cases of Parkinson’s disease (PD) are caused by genetic changes in the LRRK2 kinase. Unravelling the signalling and regulatory network of LRRK2 is a major focus of research in the MRC PPU. …more

Congratulations to Jenny van Asbeck - van der Wijst with a new step in her career as CEO of the mRNA start-up Mercurna, located in the Netherlands.

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Taran Khanam, an MRC-funded post-doctoral researcher in John Rouse’s lab in the MRC Protein Phosphorylation and Ubiquitylation Unit, has been awarded the prize for the best flash talk given at the International Joint Course on Post Transcriptional Gene Regulation and Genome Instability…more