News

Rahel Gresz, a 3rd year medical student from the University of Dundee, and Tania Savant, a 4th year neuroscience from the University of St. Andrews, spend their summer working on projects related to Parkinson's disease in the Alessi and Sammler labs. Tania looked at the impact of disease-associated genetic changes in Rab12 on the LRRK2 signalling pathway: Rab12 has been implicated in causing familial focal dystonia and is at the same time a downstream target of the Parkinson's associated LRRK2 kinase. …more

MRC PPU Researchers have been working to better understand how mutations that increase LRRK2 kinase activity cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases including Rab8A and Rab10 within a region of the “Switch-II motif” that controls the interaction with effectors such as RILPL1 and RILPL2.

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Members of the MRC PPU recently took part in an exciting event on Parkinson’s and Art organized by Werner Remmele, Secretary of the Dundee Research Interest Group (DRIG), a partnership formed with the University of Dundee and Parkinson’s patients interested in research. The event entitled “Disrupting the downward spiral: How art may help living with Parkinson’s” was held at the School of Life Sciences on October 10th and attracted nearly 20 visitors from all across Scotland including Glasgow, Edinburgh as well as across Tayside.

 

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MRC PPU scientists contributed to an interactive art exhibition entitled ‘Misprints’ by artist Daksha Patel held at the Dundee Contemporary Arts (DCA) on October 8th 2019 during Dundee Science Festival. The exhibition was inspired by research being conducted on Parkinson’s disease within the Unit.

 

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The serum- and glucocorticoid-regulated kinase-3 (SGK3) contribute resistance to cancer therapies targeting the PI3K pathway. Recent work has shown that the SGK3 isoform is upregulated in breast cancer cells treated with PI3K or Akt inhibitors and recruited and activated at endosomes, through its phox homology domain binding to PtdIns(3)P.

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On October 1st 1969 Philip Cohen became a postdoc in Edmond Fischer’s lab at the University of Washington, Seattle, USA and started his research on protein phosphorylation.

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On Sunday, 29 September 2019, researchers and friends from the MRC PPU including Professor Dario Alessi ran the Glasgow 10K race as part of Marc van Grieken’s “Shaky Team from Shaky Toun” to raise  awareness and money for research into Parkinson’s disease. Parkinson’s is the second most common neurodegenerative disorder after Alzheimer’s disease affecting 6 million people worldwide and 12,000 individuals in Scotland alone. What is needed most are treatments that slow or prevent the underlying neurodegenerative process, associated symptoms and impact on quality of life. …more

Theresita Joseph, who was jointly supervised by Miratul Muqit and Dario Alessi, has successfully defended her Masters by Research Degree (MSc) studying Parkinson’s signalling pathways in human and mouse immune cells.

 

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Theresita Joseph, who was jointly supervised by Miratul Muqit and Dario Alessi, has successfully defended her Masters by Research Degree (MSc) studying Parkinson’s signalling pathways in human and mouse immune cells.

 

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Hannah Tovell, a PhD student in Dario Alessi's lab, working in collaboration with Claire Crafter (AstraZeneca) and Alessio Ciulli and Andrea Testa in the Ciulli lab, have elaborated a compound that we have termed SGK3-PROTAC1 that induces selective degradation of SGK3 protein kinase.

 

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