A collaborative study published in Nature from Tom Deegan (formerly a postdoc in Karim Labib’s lab, now a group leader at MRC HGU, Edinburgh) and Joe Yeeles’ lab

Mutations in the gene encoding the CDKL5 kinase are among the most common genetic causes of childhood epilepsy and can also give rise to the severe neurodevelopmental condition CDD (CDKL5 Deficiency Disorder). Despite its importance for human health, the phospho–targets and cellular roles of CDKL5 are poorly understood.

We are delighted to announce that Kirby Swatek will open an independent research laboratory in the MRC PPU at the beginning of 2022.

MRC PPU researchers partnered with the Tropicalist Trust to run an event for school pupils in the upper reaches of the Himalayas, northern India to inspire them to consider a career in science.

Research from the MRC PPU has shed new light into how immune cells tolerate the presence of harmless food and symbiotic bacteria in the gut, preventing needless immune responses and inflammation in the gut. The new study is published in eLife.

We are delighted to announce that Virginia has been awarded a UKRI Future Leaders Fellowship, one of the UK’s flagship fellowship schemes for early career investiga

MRC-PPU Postdoctoral Researcher Francisco Bustos has been appointed Assistant Professor at Sanford Research, South Dakota USA

Edmond (Eddy) Fischer, who discovered the first enzyme regulated by reversible protein phosphorylation, died on August 27th 2021. He was 101. His fundamental discovery, which led to the realization that this process controls most aspects of cell life, earned Eddy together with his colleague, friend and collaborator Edwin Krebs, the 1992 Nobel Prize for Physiology or Medicine.

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is characterised by the loss of midbrain dopaminergic neurons. The physiological and molecular mechanisms leading to this neuronal loss are currently unclear; however, mitochondrial and lysosomal dysfunction seem to play a central disease role.

In a new paper just published in The EMBO Journal, Yisui Xia, Ryo Fujisawa, Remi Sonneville & Tom Deegan from Karim Labib’s group in the MRC PPU have revealed the mechanism of replisome disassembly in animal cells, using the n