Apply now for the Cancer and Genome Integrity PhD Programme

Defects in DNA replication or DNA repair can lead to mutations and other genomic alterations that give rise to cancers, and consequently tumours tend to have a high degree of genome instability. Understanding the molecular mechanisms involved in DNA replication and repair, therefore, may pave the way for new treatments for cancer. Furthermore, many of the frontline chemotherapy drugs used to treat cancer act by inducing DNA damage or perturbing DNA replication. Therefore, the mechanism cells use in sensing DNA lesions and perturbations during DNA replication has a major influence on the efficacy these therapies.

The programme has two main themes: DNA replication and DNA repair. Karim Labib’s lab….. John Rouse’s lab focuses on the molecular mechanisms underlying the signalling and repair of DNA damage, especially those that perturb DNA replication, with emphasis on control of these mechanisms by phosphorylation and ubiquitylation. John’s lab is particularly keen to understand how derailment of DNA repair causes disease, and in developing anti-tumour strategies based on inhibition of DNA repair.

We are currently accepting applications for our 2018 programme. The deadline for this round of applications is 30th April 2018, with interviews to be held at the end of May 2018. Please send a CV with contact details of three referees to, including a cover letter explaining your interest in our work.

MRC PPU 4-year PhD programme

Project Principal Investigator More Info
Genome stability pathways that regulate the mammalian replisome by ubiquitylation Karim Labib MORE