Apply now for the Cancer and Genome Integrity PhD Programme

MRC PPU Cancer and Genome Integrity PhD Programme 2022 Stipend £20,000 per annum tax-free

Defects in DNA replication or DNA repair, and in a range of other cell processes, can lead to mutations and other genomic alterations that give rise to cancers, and consequently tumours tend to have a high degree of genome instability. Understanding the molecular mechanisms involved in DNA replication and repair, therefore, may pave the way for new treatments for cancer. Furthermore, many of the frontline chemotherapy drugs used to treat cancer act by inducing DNA damage or perturbing DNA replication. Therefore, the efficacy of these therapies depends on our understanding of the mechanisms that cells use to sense and process DNA lesions and DNA replication defects.

We are looking for bright and enthusiastic young people to join our Cancer and Genome Integrity PhD Programme 2022. Our aim is to train the research leaders of tomorrow, and we provide support and training at every stage of the PhD, in a world class research institute that benefits from core funding from the MRC. We offer the option of two 4-month rotations in the first year, or alternatively students can join one lab directly for four years. Current projects can be found by clicking here. The stipend for our MRC studentships is £20,000 per annum tax-free, and our students can attend at least one international conference during the course of their PhD. You can see what some of our former PhD students are up to now by reading some of our “Alumni interviews”.

We are currently accepting applications for 2022. The closing date for applications is 30th April 2022. Please send a CV with contact details of three referees to, including a cover letter explaining your interest in our work.

MRC PPU 4-year PhD programme

Project Principal Investigator More Info
How does ubiquitin signalling help cells cope with stress? Yogesh Kulathu MORE
Non-lysine ubiquitination and its biomedical relevance Satpal Virdee MORE
Targeting DNA repair pathways for personalized cancer treatment John Rouse MORE
Genome stability pathways that control chromosome replication during mitosis in animal cells Karim Labib MORE
Dissecting how the FAM83 proteins define protein kinase CK1 substrates in cells and human diseases. Gopal Sapkota MORE
Signalling pathways controlling protein degradation upon stress Adrien Rousseau MORE
Finding the eat-me signals Ian Ganley MORE