Research | Publications

Phosphoproteomics Identifies a Bimodal EPHA2 Receptor Switch that Promotes Embryonic Stem Cell Differentiation

Fernandez-Alonso, R., Bustos, F., Budzyk, M., Helbig, A., Hukelmann, J., Lamond, A., Petsalaki, E. and Findlay, G.M.

Principal Investigator(s):
Greg Findlay
2020
PubMed

OTULIN deficiency in ORAS causes cell type specific LUBAC degradation, dysregulated TNF signaling and cell death

Damgaard RB, Elliott PR, Swatek KN, Maher ER, Stepensky P, Elpeleg O, Komander D, and Berkun Y

Principal Investigator(s):
Kirby Swatek
2019
PubMed

Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner.

Madsen, R. R. et al.

Principal Investigator(s):
Ralitsa Madsen
2019
PubMed

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

Girardini, M., Maniaci, C., Hughes, S. J., Testa, A., & Ciulli, A

Principal Investigator(s):
Chiara Maniaci
2019
PubMed

Iterative design and optimization yields a potent, fast and selective PROTAC for a target-ligase pair considered unproductive to degradation

Zoppi V, Hughes SJ, Maniaci C, Testa A, Gmaschitz T, Wieshofer C, Koegl M, Riching KM, Daniels DL, Spallarossa A, Ciulli A

Principal Investigator(s):
Chiara Maniaci
2019
PubMed

A genome-wide screen for ER autophagy highlights key roles of mitochondrial metabolism and ER-resident UFMylation

Liang JR, Lingeman E, Luong T, Ahmed S, Muhar M, Nguyen T, Olzmann JA, Corn JE

Principal Investigator(s):
Jin Rui (Amos) Liang
2019
PubMed

Insights into ubiquitin chain architecture using Ub-clipping

Swatek KN, Usher JL, Kueck AF, Gladkova C, Mevissen TET, Pruneda JN, Skern T, and Komander D

Principal Investigator(s):
Kirby Swatek
2019
PubMed

UFMylation of MRE11 is essential for maintenance of telomere length and hematopoietic stem cell survival

Lara Lee, Ana Belen Perez Oliva, Dmitri Churikov, Elena Martinez-Balsalobre, Joshua Peter, Dalicya Rahmouni, Gilles Audoly, Violette Azzoni, Stephane Audebert, Luc Camoin, Victoriano Mulero, Maria L. Cayuela, Vincent Geli, Yogesh Kulathu, Christophe Lachaud

Principal Investigator(s):
Yogesh Kulathu
2019
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Are PARKIN patients ideal candidates for dopaminergic cell replacement therapies?

Kunath T, Natalwala A, Chan C, Chen Y, Stecher B, Taylor M, Khan S, Muqit MMK.

Principal Investigator(s):
Miratul Muqit
2019
PubMed

Generation of Endogenous BMP Transcriptional Reporter Cells Through CRISPR/Cas9 Genome Editing

Hutchinson L, Bozatzi P, Macartney T, Sapkota GP.

Principal Investigator(s):
Gopal Sapkota
2019
PubMed

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements.

Deng, L, Wu, RA, Sonneville, R, Kochenova, OV, Labib, K, Pellman, D & Walter, JC

Principal Investigator(s):
Karim Labib
2019
PubMed

Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader.

Tovell, H, Testa, A, Maniaci, C, Zhou, H, Prescott, A, Macartney, T, Ciulli, A & Alessi, D

Principal Investigator(s):
Dario Alessi
2019
PubMed

Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease.

Miller, S & Muqit, MMK

Principal Investigator(s):
Miratul Muqit
2019
PubMed

Advances in targeted degradation of endogenous proteins.

Roth, S, Fulcher, L & Sapkota, G

Principal Investigator(s):
Gopal Sapkota
2019
PubMed

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.

Livingston, MJ, Wang, J, Zhou, J, Wu, G, Ganley, I, Hill, JA, Yin, X-M & Dong

Principal Investigator(s):
Ian Ganley
2019
PubMed

Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading.

Nisr, R, Shah, D, Ganley, I & Hundal, H

Principal Investigator(s):
Ian Ganley
2019
PubMed

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus.

Odqvist, L, Jevnikar, Z, Riise, R, Öberg, L, Rhedin, M, Leonard, D, Yrlid, L, Jackson, S, Mattsson, J, Nanda, S, Cohen, P, Knebel, A, Arthur, S, Thörn, K, Svenungsson, E, Jönsen, A, Gunnarsson, I, Tandre, K, Alexsson, A, Kastbom, A, Rantapää-Dahlqvist, S, Eloranta, M-L, Syvänen, A-C, Bengtsson, A, Johansson, P, Sandling, JK, Sjöwall, C, Rönnblom, L, Collins, B & Vaarala, O

Principal Investigator(s):
Philip Cohen
2019
PubMed

Profiling embryonic stem cell differentiation by MALDI TOF mass spectrometry: development of a reproducible and robust sample preparation workflow

Heap, RE, Segarra Fas, A, Blain, AP, Findlay, G & Trost, M

Principal Investigator(s):
Greg Findlay
2019
PubMed

In vitro reconstitution defines the minimal requirements for Cdc48-dependent disassembly of the CMG helicase in budding yeast

Mukherjee, P & Labib, K

Principal Investigator(s):
Karim Labib
2019
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Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

Tovell, H, Testa, A, Zhou, H, Shpiro, N, Crafter, C, Ciulli, A & Alessi, D

Principal Investigator(s):
Dario Alessi
2019
PubMed