Summary of Job Purpose and Principal Duties

The Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) is a major research facility embedded within the School of Life Sciences at the University of Dundee. Our research is aimed at understanding how protein phosphorylation and ubiquitylation regulates biological processes and how disruptions of pathways controlled by phosphorylation and/or ubiquitylation cause major human diseases such as cancer neurodegeneration and immunity disorders. One of the core technologies used by all of our researchers is mass spectrometry and the MRC PPU possess a state of the art facility equipped with an Orbitrap Fusion, two Orbitrap VelosPro, a QTrap 5500 and two MALDI-ToF-ToF systems (RapiFlex and UltrafleXtreme).

We are seeking to appoint a highly motivated and experienced scientist with considerable expertise in mass spectrometry to lead major research collaborative projects with our group leaders. The successful applicant will independently work together with our group leaders and staff within their laboratory to design and undertake collaborative mass spectrometry studies. The successful applicant will analyse and interpret proteomics data for publication and grant applications. The post holder will also be involved in the long term development of mass spectrometry systems in the MRC PPU and liaising effectively with the other research staff who work within the MRC PPU mass spectrometry facility. This position provides an exciting opportunity to be involved in world-class research projects and for the successful applicant to carve themselves a major international reputation.

Summary of Skills, Experience and Qualifications

Applicants should have significant experience of proteomics in an academic or industry environment. They should have a significant publication track record and knowledge of the operation mass spectrometers, particularly instruments available within the MRC PPU including Orbitrap Lumos, Exploris, Exactive HF-X or Bruker timsTOF. An excellent knowledge of quantitative proteomics workflows, sample preparation and data analysis of global proteomics and good understanding of statistical knowledge is essential. Previous work with phosphorylation or ubiquitylation post-translational modifications would be advantageous. A good knowledge in Python, R and/or MATLab and ability to write and develop scripts as well as modify and implement open source or published code is also desirable. The ability to work independently and communicate effectively with staff at all levels is also essential.

Candidate Requirements:

• Strong expertise in mass spectrometry and quantitative proteomics.
• Knowledge in operation mass spectrometers, particularly Orbitrap Lumos, Exploris, Exactive HF-X or Bruker timsTOF
• Strong expertise in proteomics data analysis.
• Expertise in phosphorylation and/or ubiquitylation biology is desirable.
• PhD with very good academic track record.
• Experience of managing collaborations.
• Interest in signal transduction research and how disruptions of these pathways are linked to human disease.
• Capable of working as part of a team and able to provide leadership to the rest of the team of scientists and technicians.
• Excellent communication skills and knowledge of the English language are essential.
• A good knowledge in Python, R and/or MATLab and ability to write and develop scripts as well as modify and implement open source or published code is desirable.

For further information about this position please contact Paul Davies at p.y.davies@dundee.ac.uk