Autosomal dominant missense mutations within the gene encoding for the Leucine-Rich Repeat protein Kinase 2 (LRRK2) predispose humans to develop Parkinson's disease (PD). Little is understood about how LRRK2 is regulated, or how it functions, or how …more
News
Dr. John Rouse, a Programme Leader at the Medical Research Council (MRC) Protein Phosphorylation Unit in the College of Life Sciences at the University of Dundee has been awarded the 2011 Tenovus Medal.
The …more
The …more
Craig MacKay from the MRC Protein Phosphorylation Unit has been awarded the 2010 Howard Elder Prize for his discovery in John Rouse's
lab of the FAN1 nuclease that acts as a 'molecular scissors' during DNA repair (MacKay et al, Cell 14 …more
lab of the FAN1 nuclease that acts as a 'molecular scissors' during DNA repair (MacKay et al, Cell 14 …more
Glucose sugar surges into our bloodstream after a meal, and is directed to enter muscle and fat cells under control of the hormone insulin. Understanding how insulin controls glucose distribution is of enormous practical significance because an incre …more
Craig MacKay has been awarded the 2010 Howard Elder Prize for his discovery in John Rouse's lab of the FAN1 nuclease that acts as a 'molecular scissors' during DNA repair (MacKay et al, Cell 1 …more
Pleckstrin homology (PH) domains play vital roles in enabling proteins to recognise phosphoinositides. Simon Dowler (Dario Alessi's 2nd PhD Student) identified two proteins over 10 years ago now termed the Tandem PH containing Protein-1 (TAPP1) a …more
In the latest issue of the journal Cell (Cell 143, 686-693), MRC Protein Phosphorylation Unit Director Sir Philip Cohen gives his perspective on whether components of the ubiquitin system will become as important drug targets as protein kinases for t …more
David Komander, who undertook his PhD jointly between the labs of Dario Alessi and Daan van Aalten between 2002 and 2005, has been admitted into the …more
The PDK1 kinase has been the focus of great attention since it was discovered over 13 years ago in the MRC Protein Phosphorylation Unit as a key enzyme that activated Akt. Work carried out in Dundee on PDK1 over these years have uncovered most of the …more