We are delighted to announce that Gopal Sapkota has received the prestigious Biochemical Society 2025 Industry and Academic Collaboration Award.

Protein phosphatase 2A (PP2A) is a highly abundant and essential Ser/Thr phosphatase that regulates a plethora of cellular processes. PP2A primarily operates as a holoenzyme complex, comprising one each of the scaffolding (A), regulatory (B) and catalytic (C) subunits. PPP2CA is the principal catalytic subunit of the PP2A holoenzyme complex.

Targeted protein degradation (TPD), induced by enforcing proximity in cells between a target protein and an enzyme called E3 ubiquitin ligase using small molecules has become an important drug discovery approach for targeting previously undruggable disease-causing proteins.

Phosphorylation is a reversible post-translational modification bestowed on proteins, by which phosphate is added or removed from protein substrates. Reversible phosphorylation is capable of regulating proteins in virtually every conceivable way.

Targeted protein degradation has become an exciting new drug modality. Tens of small molecule degraders, including proteolysis-targeting chimeras (PROTACs), have entered clinical trials to treat many different diseases.

A delegation from National Innovation Centre (Nepal) led by its Chairperson Dr. Mahabir Pun and European coordinator Hari K. Neupane, visited the MRC PPU on 13th April 2022.

A delegation from National Innovation Centre (Nepal) led by its Chairperson Dr. Mahabir Pun and European coordinator Hari K. Neupane, visited the MRC PPU on 13th April 2022.

Two researchers from the MRC PPU have been awarded places in the Scottish Universities Life Sciences Alliance (SULSA) Forging Futures Scheme.

Three PhD students from the MRC PPU have successfully made It through to the final round of the Biotechnology Young Entrepreneurs Scheme (YES).

Held annually by many universities worldwide, including the University of Dundee, the Three Minute Thesis (3MT) competition challenges doctoral candidates to present a compelling spoken presentation on their research topic and its significance in just three minutes to non-specialist audiences.