Patrick Pedrioli has been awarded a £400,703 BBSRC responsive mode research grant to further his research into the function and regulation of tRNA post-transcriptional modifications.
Cells tightly coordinate the composition of their proteomes in order to respond to external and internal stimuli. Degradation via the ubiquitin proteasome system and control of the amount of messenger RNA are two of the main mechanisms a cell can use to affect the abundance of a protein. The Pedrioli lab has recently demonstrated that post-transcriptional modification of transfer RNA molecules plays an important role in ensuring efficient synthesis of a subset of the proteome. The BBSRC grant will allow him to investigate the possibility that dynamic regulation of tRNA modifications provides a further mechanism cells use to alter the activity and composition of their proteomes in response to changes in growth conditions.
Cells tightly coordinate the composition of their proteomes in order to respond to external and internal stimuli. Degradation via the ubiquitin proteasome system and control of the amount of messenger RNA are two of the main mechanisms a cell can use to affect the abundance of a protein. The Pedrioli lab has recently demonstrated that post-transcriptional modification of transfer RNA molecules plays an important role in ensuring efficient synthesis of a subset of the proteome. The BBSRC grant will allow him to investigate the possibility that dynamic regulation of tRNA modifications provides a further mechanism cells use to alter the activity and composition of their proteomes in response to changes in growth conditions.