We are seeking a postdoctoral researcher with cutting edge expertise in mass spectrometry to participate in a major new global network to undertake fundamental research to understand the molecular basis of Parkinson’s disease through open and interdisciplinary collaboration. The work will focus on understanding the regulation and function of two protein kinases implicated in Parkinson’s namely LRRK2 and PINK1 and how these enzymes regulate lysosome and mitochondrial dysfunction.

The appointed researcher will be based within the laboratories of Dario Alessi and Miratul Muqit within the University of Dundee’s MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU). The project involves significant collaboration with the laboratories of Suzanne Pfeffer and Monther Abu-Remaileh at Stanford University. In addition, there will be opportunity to interact with other laboratories worldwide involved in this initiative. This project is geared towards deciphering mechanistic biology by which LRRK2 and PINK1 are linked to Parkinson’s disease.

We seek to appoint an ambitious postdoctoral researcher in Mass Spectrometry with expertise in quantitative proteomic analysis including analysis of PTMs. Experience in using instruments available within the MRC-PPU including Orbitrap Lumos, Exploris, Exactive HF-X or Bruker timsTOF is essential. A strong desire to participate and gain experience in undertaking biological studies to generate samples and validate data would be an advantage and training can be provided. A good knowledge in Python, R and/or MATLab and ability to write and develop scripts as well as modify and implement open source or published code is desirable. A good understanding of statistical knowledge is preferable. Experience in handling multi-omics (Integration of Proteomics, metabolomics or lipidomics) data is preferable but not necessary.

In your application please include a covering letter and CV. For informal enquiries please contact Professor Dario Alessi (d.r.alessi@dundee.ac.uk) or Professor Miratul Muqit (m.muqit@dundee.ac.uk)

Candidate Requirements

• PhD with outstanding academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal.
• Strong background in Mass Spectrometry is necessary.
• Capable of working in a team, and able to plan and work independently.
• Excellent communication skills and knowledge of the English language are essential.
• The candidate should have ambitions to become a successful independent researcher either in academia or the pharmaceutical/biotechnology industry.