We are recruiting a highly motivated Postdoctoral Researcher to join the laboratory of Dr Kirby Swatek. The goal of the Swatek lab is to understand the antiviral roles of a ubiquitin-like modifier called Interferon-Stimulated Gene 15 (ISG15). As its name suggests, ISG15 is highly upregulated in interferon-treated and virus-infected cells, and labels thousands of proteins to contribute to the host immune response. However, the mechanisms underlying ISG15’s contribution to antiviral immunity is largely unknown. This project focuses on the structural analysis of the writers, readers, and erasers of the ISG15 system. The postdoc will utilise several exciting new tools and reagents in the lab and expand on our recent progress in the area. A significant portion of the structural work will be performed using a Glacios Cryo Transmission Electron Microscope (Cryo-TEM) located in the School of Life Sciences. The project complements our efforts to understand the physiological roles of ISG15 modifications, and therefore, the successful applicant will have several opportunities for internal and external collaborations.
For informal enquiries or discussions, please contact Dr Kirby Swatek (firstname.lastname@example.org).
This is a 2-year MRC-funded position with a possibility of extension. The position will be on the University of Dundee Grade 7 salary scale.
Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. In this case the initial appointment would be made as a Research Assistant on the Training Grade 7 salary scale
- PhD (or will complete your PhD studies within six months of the application deadline).
- A track record of academic success.
- Expertise in cryo-EM and/or X-ray crystallography is highly desirable.
- Experience in molecular biology, biochemistry, and purification of multiprotein complexes.
- A strong background in immune signalling and ubiquitin biology would be advantageous.
- The ability to collaborate with a small multidisciplinary team of enthusiastic scientists.
- Excellent communication skills (both verbal and written).
MRC Protein Phosphorylation and Ubiquitylation Unit
The Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU, http://www.ppu.mrc.ac.uk/) is a top-tier research institute conveniently located in the School of Life Sciences at the University of Dundee, a leading university in life science research. Research Groups within the MRC PPU focus on understanding how protein phosphorylation and ubiquitylation control fundamental aspects of human health and how disruption of these cellular signals results in disease.
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