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We are recruiting a Postdoctoral Researcher to join the lab of Professor Ian Ganley. This is a fixed-term appointment until 13 March 2029.
The Ganley Lab is seeking a highly motivated postdoctoral researcher to investigate how distinct autophagy pathways are coordinated with mitophagy at the molecular level. Our work focuses on understanding how signalling networks integrate nutrient sensing, mitochondrial quality control, and selective autophagy to maintain cellular homeostasis. The successful candidate will use state-of-the-art cell biology, biochemistry, and imaging approaches to define how core autophagy machinery interfaces with pathway-specific regulators. The project offers opportunities to explore pathway crosstalk, signaling hierarchies, and the mechanisms that determine cargo selectivity.
Researchers will benefit from the MRC PPU’s interdisciplinary and collaborative environment, strong links with industry, and opportunities for public and patient engagement. This is an exciting opportunity to contribute to cutting-edge research, gain training in advanced techniques, and establish a strong international scientific profile.
Relevant lab publications:
Lorentzen KC, Prescott AR, Ganley IG. Artificial targeting of autophagy components to mitochondria reveals both conventional and unconventional mitophagy pathways. Autophagy. 2025 Feb;21(2):315-337. doi: 10.1080/15548627.2024.2395149. PMID: 39177530.
Longo M, Bishnu A, Risiglione P, Montava-Garriga L, Cuenco J, Sakamoto K, MacKintosh C, Ganley IG. Opposing roles for AMPK in regulating distinct mitophagy pathways. Mol Cell. 2024 Nov 21;84(22):4350-4367.e9. doi: 10.1016/j.molcel.2024.10.025. PMID: 39532100.
Wilhelm LP, Zapata-Muñoz J, Villarejo-Zori B, Pellegrin S, Freire CM, Toye AM, Boya P, Ganley IG. BNIP3L/NIX regulates both mitophagy and pexophagy. EMBO J. 2022 Dec 15;41(24):e111115. doi: 10.15252/embj.2022111115. PMID: 36215693.
Your priorities will include:
Biochemical and cell biological characterisation of autophagy/mitophagy in vitro and in vivo.
Public and patient involvement and engagement presentations.
Dissemination of protocols and data openly and through formal peer-reviewed publications.
Advising and mentoring undergraduate and PhD students.
Who we’re looking for:
PhD in cell biology, biochemistry, or a related discipline and a publication record in internationally recognised peer-reviewed journals.
Have an interest in signal transduction research and how disruptions of these pathways are linked to human disease.
Ability to work independently but also within a team, and an open and collaborative approach to science.
Excellent communication skills and knowledge of the English language are essential.
To apply on-line please visit: www.dundee.ac.uk/jobs. If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number
The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment. We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.
The University of Dundee has received the Athena SWAN Bronze Award which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.
The University of Dundee is a Scottish Registered Charity, No. SC015096.