Abstract:

Post-translational modifications composed of Ubiquitin and Ubiquitin-like modifiers (Ubls) regulate a wide variety of cellular processes. Research in my lab combines chemical biology, protein chemistry and structural biology to dissect mechanisms of DUBs and Ubl proteases, and to explore their ligandability with small molecule modulators. In my talk, I will present unpublished work from the lab and this abstract will be updated closer to the date of the seminar.

Bio:

Malte Gersch is a research group leader at the Max Planck Institute of Molecular Physiology in Dortmund, Germany, and jointly affiliated with the Department of Chemistry and Chemical Biology of TU Dortmund University. He obtained a B.Sc. in Chemistry and Biochemistry and an M.Sc. in Chemistry from LMU Munich. Following a research internship with Prof. Matthew Bogyo at Stanford University, he pursued his PhD in Chemical Biology with Prof. Dr. Stephan A. Sieber at TU Munich. He subsequently joined the laboratory of Dr. David Komander at the MRC LMB in Cambridge for post-doctoral training. In 2019, he started his independent laboratory in Dortmund through an Emmy-Noether fellowship awarded by the Deutsche Forschungsgemeinschaft (DFG).