Lab Member | Brune Le Chatelier

PhD Rotation Student
with

Brune Le Chatelier
Current Lab Member
(
2025
- Now )

I joined the Sapkota Lab in March 2025, and my PhD project investigates the phosphoproteome of CK1δ and CK1ε. There is some evidence that the CK1 kinase family phosphorylates proteins involved in neurodegenerative diseases like tau and TDP-43 which, once hyperphosphorylated, aggregate. Through these phosphoproteomic analyses, my project aims to better understand the regulation underlying this hyperphosphorylation and aggregation, a hallmark process in the pathogenesis of neurodegenerative diseases like Alzheimer's disease or amyotrophic lateral sclerosis.

Before joining my PhD, I earned a MSc in Dementia Neuroscience at UCL, where I probed Parkin mRNA transfection as a strategy to boost mitophagy in neuroblastoma under Prof. Hélène Plun-Favreau's supervision. Prior to my MSc, I completed a BSc in Neuroscience from the University of St Andrews, during which I earned an undergraduate research fellowship to investigate the role of thalamocortical circuits in the regulation of motor control using optogenetics in mice at Emory University (USA) under Prof. Dieter Jaeger's supervision.

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Brune
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