Lab Member | Purbasha Bhattacharya

Postdoctoral Researcher
with

Purbasha Bhattacharya
Current Lab Member
(
2024
- Now )

I joined the lab in March 2024 as a Postdoctoral Research Assistant. I have been working in two projects majorly in the lab right now: investigating the effect of LRRK2 inhibition in a mouse model of Crohn’s disease and understanding the role of LRRK2 in neutrophils.

Before joining the lab, I completed my bachelor’s degree from Delhi University, India in biomedical sciences and master’s degree from Jamia Millia Islamia, India in biosciences. I received my PhD from Institute of Genomics and Integrative Biology of the Council of Scientific and Industrial Research (CSIR-IGIB), India under the supervision of Dr. Shantanu Sengupta and Dr. Manikandan Subramanian, Queen Mary University of London. My doctoral research focused on understanding the role of efferocyte-derived extracellular vesicles in inflammation resolution and progression of atherosclerosis. As a part of the research, I have shown that efferocytes release EVs rich in prosaposin (PSAP) which binds to GPR37 on macrophages and through ERK axis increases the expression of TIM4 in a feed-forward loop which helps these macrophages to carry out the better resolution of inflammation. Therapeutically, when these EVs are given treatment to advanced atherosclerotic mice, the progression of the disease is inhibited.

Country of Origin:
India
India
Contact :