Daniel Fazakerley, who recently received his PhD from the University of Bath, UK, working with Geoffrey Holman, has been awarded a Sir Henry Wellcome Postdoctoral Fellowship. This prestigious four year award provides the most promising newly qualified postdoctoral researchers with an opportunity to work in outstanding laboratories in the UK and overseas to help them to develop into independent scientists. During Daniel's Fellowship he will first work for three years in David James's laboratory at the Garvan Institute, Sydney, Australia before transferring for his 4th year to Kei Sakamoto's laboratory in the MRC PPU.

Daniel is interested in understanding how signalling pathways control metabolism and the degree to which these pathways are altered in insulin-resistant or diabetic states. He will combine proteomic approaches measuring how the phosphorylation of many cellular proteins change in response to insulin and exercise, combined with mathematical modeling. The goal is to work out complex protein interactions within cells and identify key components of signalling networks involved in the transition from a healthy to an insulin-resistant state.