Scientists within the halls of the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) have been focused on elucidating the mechanisms underlying two of the most prolific post-translational modification events that occur in cells for a number of years. These events are critical for the normal function of cells and signalling within each of our bodies – and indeed, when things go wrong (as in disease), abnormal signalling events by way of phosphorylation or ubiquitylation, are often the culprit. But how best to convey the importance of these events to the world at large?



Working with a team of scientists, writers, and animators – along with a Hollywood icon – the MRC PPU is pleased to share a new video that describes one of the most significant components of the research carried out in the Unit – communication between cells. Entitled ‘The Heart of Research and Discovery' and narrated by the stage and film actor Brian Cox (also Rector of The University of Dundee!), the animation conveys the history and significance of one type of signalling event – phosphorylation. It further goes on to illustrate the impact of phosphorylation on basic biology, health and disease, and culminates with describing the role the MRC PPU plays in the development of therapeutics focused on the enzymes that regulate phosphorylation. It is hoped that this animation (made in collaboration with the company Vivomotion) will be helpful for the general public – from patients and caregivers, to students – so that they can gain insight into the implications of the Unit's research for diseases such as cancer, hypertension and neurodegeneration.

To view the video please click here.