Action

B-RAF

Alt Name

Approval Jurisdiction

2011 FDA, 2012 EMA

Approved for clinical use

Metastatic Melanoma BRAFV600E

Brutto

C₂₃H₁₈ClF₂N₃O₃S

CAS

1029872-54-5

Commercial Vendor

Roche Plexxicon

Compound Image

Vemurafenib.png

Compound name

Vemurafenib

InChI

InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)

InChI Key

GPXBXXGIAQBQNI-UHFFFAOYSA-N

MW

489.92

PubChem CID

42611257

Reference

Reference 2

SMILES

CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F

Approved Drug List

1