Dates: October 2008 - April 2013

Current Position: Postdoctoral Researcher in Junying Yuan's lab, Harvard Medical School, Department of Cell Biology

Publications Generated While in the Lab:

Uncoupling the Warburg effect from cancer.

Najafov A, Alessi DR.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19135-6. doi: 10.1073/pnas.1014047107. Epub 2010 Nov 1. No abstract available.

PMID: 21041650

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.

Najafov A, Sommer EM, Axten JM, Deyoung MP, Alessi DR.

Biochem J. 2011 Jan 15;433(2):357-69. doi: 10.1042/BJ20101732.

PMID: 21087210

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.

Hoxhaj G, Najafov A, Toth R, Campbell DG, Prescott AR, MacKintosh C.

J Cell Sci. 2012 Oct 1;125(Pt 19):4662-75. doi: 10.1242/jcs.110296. Epub 2012 Jul 13.

PMID: 22797923

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.

Najafov A, Shpiro N, Alessi DR.

Biochem J. 2012 Dec 1;448(2):285-95. doi: 10.1042/BJ20121287.

PMID: 23030823

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development.

Venigalla RK, McGuire VA, Clarke R, Patterson-Kane JC, Najafov A, Toth R, McCarthy PC, Simeons F, Stojanovski L, Arthur JS.

EMBO J. 2013 Apr 3;32(7):1008-22. doi: 10.1038/emboj.2013.40. Epub 2013 Mar 5.

PMID: 23463102