For years the Akt/PKB research field has been in turmoil, trying to understand how the activating phosphorylation of Akt/PKB at Ser473 is regulated. In the past month, papers in a recent issue of Molecular Cell (Gao et al., 2005) and in Science (Sarbassov et al., 2005) may have identified the phosphatase and kinase acting on this residue.
Author(s):
Bayascas, J. R., Alessi, D. R.
PubMed:
15837416
Citation:
Bayascas, J. R., Alessi, D. R.
Bayascas, J. R., Alessi, D. R.
Mol Cell
2005
18
143-5
PMID: 15837416