Dates:

October 2011 - September 2015

Current Position:

Post-doctoral scientist, Pico Caroni lab, Friedrich Miescher Institute, Basel, Switzerland

Publications Generated While in the Lab:

Han, C., Pao, K. C., Kazlauskaite, A., Muqit, M. M. and Virdee, S. (2015). A Versatile Strategy for the Semisynthetic Production of Ser65 Phosphorylated Ubiquitin and Its Biochemical and Structural Characterisation. Chembiochem 16, pp. 1574-1579

Kazlauskaite, A., Martinez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H. and Muqit, M. M. (2015). Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. EMBO Rep 16, pp. 939-954

Kazlauskaite, A. and Muqit, M. M. (2015). PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease. FEBS J 282, pp. 215-223

Rogerson, D. T., Sachdeva, A., Wang, K., Haq, T., Kazlauskaite, A., Hancock, S. M., Huguenin-Dezot, N., Muqit, M. M., Fry, A. M., Bayliss, R. and Chin, J. W. (2015). Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog. Nat Chem Biol 11, pp. 496-503

Kazlauskaite, A., Kelly, V., Johnson, C., Baillie, C., Hastie, C. J., Peggie, M., Macartney, T., Woodroof, H. I., Alessi, D. R., Pedrioli, P. G. and Muqit, M. M. (2014). Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity. Open Biol 4, pp. 130213

Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M. and Muqit, M. M. (2014). Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. Biochem J 460, pp. 127-139

Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., Macartney, T. J., Deak, M., Knebel, A., Alessi, D. R. and Muqit, M. M. (2012). PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol 2, pp. 120080