Date: October 2002- June 2006
Current Position: Director, Oncology Research, Rubedo Life Sciences, inc.
Publications Generated While in the Lab:
1. Vitari, A.C., Deak, M., Collins, B.J. Morrice, N.A., Prescott, A.R., Phelan, A., Humphreys, S. & Alessi, D.R. (2004) WNK1, the kinase mutated in an inherited high blood pressure syndrome, is a novel PKB/Akt substrate.
Biochemical J. 378, 257-68.
2. Vitari, A.C., Deak, M., Morrice, N.A. and Alessi, D.R. (2005) The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome, phosphorylate and active SPAK and OSR1 protein kinases. Biochemical J. 391, 17-24.
3. Vitari, A.C., Thastrup, J., Rafiqi, F., Deak, M., Morrice, N.A., Karlsson H.K.R and Alessi, D.R. (2006) Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. Biochem. J. 397, 223-231.
4. Zagórska A, Pozo-Guisado E, Boudeau J, Vitari AC, Rafiqi FH, Thastrup J, Deak M, Campbell DG, Morrice NA, Prescott AR, Alessi DR. (2007) Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. J Cell Biol. 176(1), 89-100.