Date: June 1996 - February 1999

Current Position: Group Leader, Department of Biochemistry and Molecular Biology, University Autonoma Barcelona, Campus: Bellaterra, Cerdanyola, 08193, Spain

Publications Generated While in the Lab:

1. Alessi, D.R., Deak, M., Casamayor, A., Caudwell, F.B., Morrice, N., Norman, D.G., Gaffney, P., MacDougall, C., Harbison, D., Ashworth, A. & Bownes, M. (1997). 3-Phosphoinositide dependent protein kinase-1 (PDK1); structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol. 7, 776-789.

2. Currie, R.A., Walker, K.S., Gray, A., Deak, M., Casamayor, A., Downes, C.P., Cohen, P. & Alessi, D.R. & Lucocq, J. (1999). Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem, J. 337, 575-583.

3. Casamayor, A., Torrance, P.D., Kobayashi, T., Thorner, J. & Alessi, D.R. (1999). Functional counterparts of mammalian 3-phosphoinositide-dependent protein kinase-1 (PDK1) and serum- and glucocorticoid-induced protein kinase (SGK) are components of a signaling pathway in the yeast Saccharomyces cerevisiae. Curr. Biol. 9, 186-197.

4. Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C.P. & Alessi, D.R. (1999). PDK1 and PDK2 may be the same enzyme; PDK1 displays PDK2 activity in the presence of a synthetic peptide. Curr. Biol. 9, 393-404.

5. Deak, M., Casamayor, A., Currie, R.A., Downes, C.P. & Alessi, D.R. (1999). Characterisation of a Plant PDK1 homologue which contains a PH domain. FEBS Lett. 451, 220-226.

6. Casamayor, A., Morrice, N.M. & Alessi, D.R. (1999). Phosphorylation of Ser241 is essential for the activity of PDK1; Identification of five sites of phosphorylation in vivo. Biochem. J. 342, 287-292.

7. Biondi, R.M., Cheung, P.C.F., Casamayor, A., Deak, M., Currie, R.A. & Alessi, D.R. (2000). Identification of a pocket in the PDK1 kinase domain which interacts with PIF and the C-terminal residues of PKA. EMBO J. 19, 979-988.

8. Balendran, A., Biondi, R.M., Cheung, P., Casamayor, A., Deak, M. & Alessi. D.R, (2000). A PDK1 docking site is required for the phosphorylation of PKCz and PRK2 by PDK1. J. Biol. Chem. 275, 20806-20813.

9. Grillo, S., Gremeaux, T., Casamayor, A., Alessi, D.R., Le Marchand-Brustel Y., Tanti, J.F. (2000). Peroxovanadate induces tyrosine phosphorylation of phosphoinositide dependent protein kinase-1. Potential involvement of Src kinase. Eur. J. Biochem. 267, 6642-6649.