Lab Member | David Komander

PhD Student
with

David Komander
Past Lab Member
(
2002
-
2005
)

Date: January 2002 - January 2005

Current Position: Professor and Head of Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research / Department of Medical Biology, University of Melbourne, Victoria, Australia


Publications Generated While in the Lab:

1. Biondi, R.M., Komander, D., Thomas, C.C., Lizcano, J.M., Deak, M., Alessi, D.R. and van Aalten, D.M.F. (2002) High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site. EMBO J 21, 4219-4228.

2. Komander, D., Kular,G.S., Bain, J., Alessi, D.R. and van Aalten, D.M.F. (2003) Structural basis for UCN-01 inhibition of PDK1. Biochem J. 375, 255-262.

3. Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R.C., Bain, J., Elliott, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R. & van Aalten, D.M.F. (2004) Interactions of LY333531 and other bisindoyl maleimide inhibitors with PDK1. Structure 12, 215-26.

4. Mora, A., Komander, D., van Aalten, D.M.F. and Alessi, D.R. (2004) PDK1, the master regulator of AGC-kinase signal transduction. Seminars in Cell & Developmental Biology 15, 161-170.

5. Komander, D., Deak, M., Morrice, N., van Aalten, D.M. (2004) Purification, crystallization and preliminary X-ray diffraction of a proteolytic fragment of PDK1 containing the pleckstrin homology domain. Acta Crystallogr D Biol Crystallogr. 60, 314-316.

6. Komander, D., Fairservice, A., Deak, M., Kular, G.S., Prescott, A.R., Downes, C.P., Safrany, S.T., Alessi, D.R., and van Aalten, D.M.F. (2004) Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J. 23, 3918-28.

7. Boudeau, J., Scott, J., Resta, N., Deak, M., Kieloch, A., Komander, D., Hardie, D.G., Prescott, A.R., van Aalten, D.M.F. and Alessi, D.R. (2004) Analysis of the LKB1:STRAD:MO25 complex. J. Cell Science. 117, 6365-6375.

8. Komander, D., Kular, G., Deak, M., Alessi, D.R. and van Aalten, D.M.F. (2005) Analysis of PDK1 activation, stability and substrate binding. J. Biol. Chem. 280, 8797-18802.

9. Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR (2008) Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol. 28(10), 3258-72.

Contact
David
Komander
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