Lab Member | Ed McManus

PhD Student

Ed McManus Portrait
Past Lab Member

Date: October 2001 - March 2005

Current Position: CEO, Deliveroo, Australia

Publications Generated While in the Lab:

1. McManus, E.J. & Alessi, D.R. (2002) TSC1-TSC2: a complex tale of PKB-mediated S6K regulation. Nat. Cell Biol.4, E214-E216.

2. McManus, E.J., Collins, B.J., Ashby, P.R., Prescott, A.R., Murray-Tait, V., Armit, L.J., Arthur, J.S.C. and Alessi, D.R. (2004) The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J, 23, 2071–2082.

3. McManus, E.J. and Alessi, D.R. (2004) Meeting report: Cancer, Oncogenes and Signal Transduction.Genome Biology 5:332.

4. McManus, E.J., Sakamoto, K., Armit, L.J., Ronaldson, L., Shpiro, N., Marquez, R. and Alessi, D.R. (2005) Role that phosphorylation of GSK3 plays in insulin and Wnt-signalling defined by knockin analysis. EMBO J 24, 1571-1583.

5. Mora, A., Sakamoto, K., McManus, E.J. & Alessi, D.R. (2005) Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart. FEBS Letters 579, 3632-3638.

6. Ruiz-Alcaraz, A.J., Liu, H.K., Cuthbertson, D.J., McManus, E.J., Akhtar, S., Lipina, C., Morris, A.D., Petrie, J.R., Hundal, H.S., Sutherland, C. (2005) A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration. Biochem J. 392, 345-352.

7. Lipina, C., Huang, X., Finlay, D., McManus, E.J., Alessi, D.R., Sutherland, C. (2005) Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3. Biochem J. 392, 633-639.