Dates: September 2005-October 2009
Current Position: Sir Henry Dale Fellow, Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, UK
Publications Generated While in the Lab:
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.
Filippi BM, de Los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR.
EMBO J. 2011 May 4;30(9):1730-41
Zeqiraj, E., Filippi, B. M., Deak, M., Alessi, D. R. and van Aalten, D. M. (2009). Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science. 326, pp. 1707-11
Zeqiraj, E., Filippi, B. M., Goldie, S., Navratilova, I., Boudeau, J., Deak, M., Alessi, D. R. and van Aalten, D. M. (2009). ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. PLoS Biol. 7, pp. e1000126
Alessi, D. R. and Zeqiraj, E. (2007). Protein Phosphorylation. The Biochemist. 29, pp. 20-23