Lab Member | Jose Lizcano

Postdoctoral Researcher

Jose M Lizcano
Past Lab Member

Date: November 2000 - August 2004

Current Position: Associate Professor, Director of Department of Biochemistry, Faculty of Medicine. University Autonoma Barcelona, Spain

Publications Generated While in the Lab:

1: Lizcano J.M., Goransson O., Toth R., Deak M., Morrice N.A., Boudeau J., Hawley S.A., Udd L., Makela T.P., Hardie D.G., Alessi D.R. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 2004;23:833-43.

2: Canto C., Suarez E., Lizcano J.M., Grino E., Shepherd P.R., Fryer L.G., Carling D., Bertran J., Palacin M., Zorzano A., Guma A. Neuregulin signaling on glucose transport in muscle cells. J Biol Chem. 2004;279:12260-8.

3: Lizcano J.M., Alrubaie S., Kieloch A., Deak M., Leevers S.J., Alessi D.R. Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. Biochem J. 2003;374:297-306.

4: Biondi R.M., Komander D., Thomas C.C., Lizcano J.M., Deak M., Alessi D.R., van Aalten D.M. High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site. EMBO J. 2002;21:4219-28.

5: Lizcano J.M., Deak M., Morrice N., Kieloch A., Hastie C.J., Dong L., Schutkowski M., Reimer U., Alessi D.R. Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo. J Biol Chem. 2002;277:27839-49.

6: Lizcano J.M., Alessi D.R. The insulin signalling pathway. Curr Biol. 2002;12:R236-8.

7: Sapkota G.P., Kieloch A., Lizcano J.M., Lain S., Arthur J.S., Williams M.R., Morrice N., Deak M., Alessi D.R. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. J Biol Chem. 2001;276:19469-82

8: Lizcano J.M., Morrice N., Cohen P. Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem J. 2000;349:547-57.

9. Jaleel, M., McBride, A., Lizcano, J.M., Deak, M., Toth, R., Morrice, N.A. and Alessi, D.R. (2005) Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.FEBS Lett. 579, 1417-1423.

Country of Origin: Catalunya