Dates: February 2009-August 2013

Current position: Associate Lecturer and Researcher, Universidad Nacional Autónoma de México (UNAM), Faculty of Medicine

Papers generated while in the lab:

Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MIH, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle K. (2016) Functional kinomics establishes a critical node of volume-sensitive cation-Cl ^- cotransporter regulation in the mammalian brain. Sci Rep 6, 35986 PMID 27782176

de Los Heros, P., Alessi, D. R., Gourlay, R., Campbell, D. G., Deak, M., Macartney, T. J., Kahle, K. T. and Zhang, J. (2014). The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. Biochem J 458, pp. 559-573

Melo, Z., de los Heros, P., Cruz-Rangel, S., Vazquez, N., Bobadilla, N. A., Pasantes-Morales, H., Alessi, D. R., Mercado, A. and Gamba, G. (2013). N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling. J Biol Chem 288, pp. 31468-31476

Alvarez DP, Vazquez N, Castaneda-Bueno M, de Los Heros P, Cortes-Gonzalez C, Moreno E, Meade P, Bobadilla NA, Gamba G (2012) WNK3-SPAK interaction is required for the modulation of NCC and other members of the SLC12 family. Cell Physiol Biochem 29(1-2), 291-302 PMID 22415098

Filippi, B. M., de Los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. and Alessi, D. R. (2011). MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases. EMBO J 30, pp. 1730-1741

Richardson, C., Sakamoto, K., de Los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. and Alessi, D. R. (2011). Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci 124, pp. 789-800