Date: October 2005 - April 2011

Current Position: Senior Scientist/Study Manager at Molecular Partners, Zurich, Switzerland

Swiss Federal Institute of Technology Lausanne (EPFL)

EPFL SV ISREC CMSO, Station 19, CH-1015 Lausanne, Switzerland

Publications Generated While in the Lab:

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.

Pearce LR, Sommer EM, Sakamoto K, Wullschleger S, Alessi DR.

Biochem J. 2011 May 15;436(1):169-79

Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice.

García-Martínez JM, Wullschleger S, Preston G, Guichard S, Fleming S, Alessi DR, Duce SL.

Br J Cancer. 2011 Mar 29;104(7):1116-25

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis.

Wullschleger S, Wasserman DH, Gray A, Sakamoto K, Alessi DR.

Biochem J. 2011 Mar 1;434(2):265-74

How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance.

Wullschleger S, Sakamoto K, Johnstone L, Duce S, Fleming S, Alessi DR.

Dis Model Mech. 2011 Jan;4(1):95-103

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.

Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, McBurnie W, Fleming S, Alessi DR.

Biochem J. 2008 Jun 1;412(2):211-21

Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.

Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR.

Mol Cell Biol. 2008 May;28(10):3258-72

Identification of Protor as a novel Rictor-binding component of mTOR complex-2.

Pearce LR, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR.

Biochem J. 2007 Aug 1;405(3):513-22

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.

Göransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR.

J Cell Sci. 2006 Oct 1;119(Pt 19):4059-70. Epub 2006 Sep 12