Studentship | Location,location, location: DNA damage sensors which launch protective responses to DNA damage

MRC Funded
Project with

DNA damage happens at very high frequency in the cells in our bodies – meaning that the blueprint for the proper functioning of cells could be altered unless the mistakes are spotted and corrected. We recently started a search for new surveillancve factors in human cells that can detect damaged DNA and help to launch the DDR “DNA damage response” that stops secondary consequences of DNA damage such as mutations, disease or cell death. Specifically, we screened for factors in cells capable of recognizing damaged DNA inside the nucleus, which we induce experimentally using lasers attached to a confocal microscope. These experiments revealed a range of enzymes that rapidly translocate to damaged DNA. We now wish to understand in detail how these factors recognize damaged DNA and how they participate in DNA repair and other protective responses. We’re alos interested in how mutations in these factors cause human diseases. I’m looking for bright enthusiastic PhD students to join my team to tackle these questions. Students will use techniques such as culturing cells, genome editing, state-of-the-art confocal microscopy, live cell imaging, whole genome sequencing, and using lasers to induce DNA damage.

Application Procedure

We are currently accepting applications for our 2023 programme. To apply, please send the following to mrcppu-phd-admin@dundee.ac.uk
 

  • Cover letter explaining your interest in our work. Please also indicate which group(s) you are most interested in, and whether you prefer rotations or would like to join one lab directly.
  • CV with contact details of three referees.


Applications from overseas students are welcome. The closing date for the first round of applications is January 31st 2022