Miratul Muqit, a Wellcome Intermediate Fellow working with Dario Alessi, has been appointed a Consultant Neurologist at Ninewells Hospital in Dundee. Miratul was the first clinician to be appointed to the MRC-PPU and now becomes the first to reach th …more

The PI 3-kinase-mTOR signalling pathway is activated in the majority of human tumours and there is great interest in assessing whether inhibitors of PI 3-kinase or mTOR kinase would have efficacy in treating cancers in which this pathway is over acti …more

A few years ago at the beginning of her PhD Laura Pearce identified novel components of the mTOR complex 2 (mTORC2) that she termed Protor-1 and Protor-2. Laura found that Protor isoforms interacted with the mTORC2 component Rictor. Protor-1 and Prot …more

Beatrice Filippi and Paola de los Heros MRC Unit postdocs working in Dario Alessi's lab have reevaluated the role of the MO25 scaffolding protein, that Jerome Boudeau - a previous postdoc now running a lab in Montpellier - discovered was a key compon …more

Hugh Nimmo, the first postdoctoral fellow of Unit Director Philip Cohen, has been elected a Fellow of the Royal Society of Edinburgh. Hugh worked in Philip's laboratory from 1973 to 1976 on a grant funded by the British Diabetic Association (now call …more

Autosomal dominant missense mutations within the gene encoding for the Leucine-Rich Repeat protein Kinase 2 (LRRK2) predispose humans to develop Parkinson's disease (PD). Little is understood about how LRRK2 is regulated, or how it functions, or how  …more

Dr. John Rouse, a Programme Leader at the Medical Research Council (MRC) Protein Phosphorylation Unit in the College of Life Sciences at the University of Dundee has been awarded the 2011 Tenovus Medal.

The  …more

In the Spotlight in the latest edition of the Biochemical Journal is a paper by Kumara Dissanayake in Carol MacKintosh's group "Erk/p90RSK/14-3-3 signalling impacts on expression of PEA3 …more

Craig MacKay from the MRC Protein Phosphorylation Unit has been awarded the 2010 Howard Elder Prize for his discovery in John Rouse's

lab of the FAN1 nuclease that acts as a 'molecular scissors' during DNA repair (MacKay et al, Cell 14 …more

Glucose sugar surges into our bloodstream after a meal, and is directed to enter muscle and fat cells under control of the hormone insulin. Understanding how insulin controls glucose distribution is of enormous practical significance because an incre …more