Wnt signalling pathway is fundamental during development but it’s overactivity drives many cancers, particularly colorectal cancers (CRCs). New research led by Karen Dunbar (postdoctoral fellow in Sapkota lab) has uncovered FAM83F as a novel mediator of the Wnt signalling pathway.

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Congratulations to MRC PPU PIs Gopal Sapkota and Satpal Virdee who have been promoted to Professorial Chairs by the University of Dundee.

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Congratulations to MRC PPU PIs Gopal Sapkota and Satpal Virdee who have been promoted to Professorial Chairs by the University of Dundee.

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The three-year alliance will allow knowledge, skills and technology sharing, as well as two joint postdoctoral positions, in order to accelerate discoveries on molecular metabolic signalling in control of glucose homeostasis …more

The ability to selectively and rapidly degrade a protein of interest (POI) inside cells is desirable for studying its function and in therapeutics. Previously, the Sapkota Lab had developed the Affinity-directed PROtein Missile (AdPROM) system for constitutive degradation of POIs (Fulcher et al., 2016 & 2017).

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The Sapkota lab developed the Affinity-directed PROtein Missile (AdPROM) system for targeted degradation of endogenous proteins inside cells. In principle, by deploying binders of specific proteins attached to destruction signals as “protein missiles”, any intracellular protein can be destroyed rapidly.

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Greg Findlay and Francisco Bustos, a postdoctoral researcher in Greg’s group, were recently awarded a £20,000 Tenovus Scotland Research Grant to engineer an RNF12 E3 ligase substrate degrader as a therapeutic strategy in Tonne-Kalscheuer Syndrome (TOKAS) intellectual disability.

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Luke Fulcher, who has just completed his PhD work in Gopal Sapkota’s lab, has been awarded the prestigious University of Dundee School of Life Sciences Howard Elder Prize for 2019.

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In MRC PPU we are extremely proud that in 2019, a total of 13 PhD students and 1 MSc student defended their theses, and everyone passed with flying colours! As part of the defence, each student gave a 45-minute talk describing their PhD research, to packed lecture rooms.

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The concerted action of several protein kinases helps orchestrate the error-free transition through a mammalian cell division cycle.

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