Research | Publications

Year

Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases.

Mathur S, Fletcher AJ, Branigan E, Hay RT, Virdee S.

Principal Investigator(s):
Satpal Virdee
2020
PubMed

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72

Vieweg S, Mulholland K, Brauning B, Kacharia N, Lai YC, Toth R, Singh PK, Volpi I, Sattler M, Groll M, Itzen A, Muqit MMK

Principal Investigator(s):
Miratul Muqit
2020
PubMed

HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation

Zhao, J-F., Rodger, C., Allen, G. F. G., Weidlich, S. & Ganley, I. G

Principal Investigator(s):
Ian Ganley
2020

Semi-automated quantitation of mitophagy in cells and tissues

Montava-Garriga, L., Singh, F., Ball, G. & Ganley, I

Principal Investigator(s):
Ian Ganley
2020
PubMed

The Identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets

Zachari, M., Rainard, J. M., Pandarakalam, G. C., Robinson, L., Gillespie, J., Rajamanickam, M., Hamon, V., Morrison, A., Ganley, I. G. & McElroy, S. P

Principal Investigator(s):
Ian Ganley
2020
PubMed

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses.

Hutchinson, L.D., Darling, N.J., Nicolaou, S, Gori, I., Squair, D., Cohen, P., Hill, C.S. and Sapkota, G.P

Principal Investigator(s):
Gopal Sapkota, Philip Cohen
2020
PubMed

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2

Waschbusch, D., Purlyte, E., Pal, P., McGrath, E., Alessi, D.R., Khan, A.R

Principal Investigator(s):
Dario Alessi
2020
PubMed

Advances in elucidating the function of protein kinase LRRK2 in normal cells and Parkinson's Disease

Taylor, M., Alessi, D.R

Principal Investigator(s):
Dario Alessi
2020
PubMed

Outstanding questions in mitophagy: what we do and do not know

Montava Garriga, L & Ganley

Principal Investigator(s):
Ian Ganley
2020
PubMed

HOIL-1, an atypical E3 ligase that controls MyD88 signalling by forming ester bonds between ubiquitin and components of the Myddosome

Cohen, P, Kelsall, IR, Nanda, SK & Zhang, J

Principal Investigator(s):
Philip Cohen
2020
PubMed

Phosphoproteomics Identifies a Bimodal EPHA2 Receptor Switch that Promotes Embryonic Stem Cell Differentiation

Fernandez-Alonso, R., Bustos, F., Budzyk, M., Helbig, A., Hukelmann, J., Lamond, A., Petsalaki, E. and Findlay, G.M.

Principal Investigator(s):
Greg Findlay
2020
PubMed

Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover

Heo, S., Diering, G. H., Na, C. H., Nirujogi, R. S., Bachman, J. L., Pandey, A. and Huganir, R. L.

Principal Investigator(s):
Raja Nirujogi
2019
PubMed

Proteomic Analysis of Plasmodium Merosomes: The Link between Liver and Blood Stages in Malaria

Shears, M.J., Nirujogi, R. S., Swearingen, K.E., Renuse, S., Mishra, S., Panga, J.R., Mortiz, R.L., Pandey, A and Sinnis,P

Principal Investigator(s):
Raja Nirujogi
2019
PubMed

Integrated Transcriptomic and Proteomic Analysis of Primary Human Umbilical Vein Endothelial Cells

Madugundu, A.K., Na, C.H., Nirujogi, R.S., Renuse, S., Kim, K.P., Burns, K.H., Wilks, C., Lingmead, B., Ellis, S.E., Collado-Terres, L., Halushka, M.K., Kin, M.S. and Pandey, A

Principal Investigator(s):
Raja Nirujogi
2019
PubMed

OTULIN deficiency in ORAS causes cell type specific LUBAC degradation, dysregulated TNF signaling and cell death

Damgaard RB, Elliott PR, Swatek KN, Maher ER, Stepensky P, Elpeleg O, Komander D, and Berkun Y

Principal Investigator(s):
Kirby Swatek
2019
PubMed

Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner.

Madsen, R. R. et al.

Principal Investigator(s):
Ralitsa Madsen
2019
PubMed

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

Girardini, M., Maniaci, C., Hughes, S. J., Testa, A., & Ciulli, A

Principal Investigator(s):
Chiara Maniaci
2019
PubMed

Iterative design and optimization yields a potent, fast and selective PROTAC for a target-ligase pair considered unproductive to degradation

Zoppi V, Hughes SJ, Maniaci C, Testa A, Gmaschitz T, Wieshofer C, Koegl M, Riching KM, Daniels DL, Spallarossa A, Ciulli A

Principal Investigator(s):
Chiara Maniaci
2019
PubMed

A genome-wide screen for ER autophagy highlights key roles of mitochondrial metabolism and ER-resident UFMylation

Liang JR, Lingeman E, Luong T, Ahmed S, Muhar M, Nguyen T, Olzmann JA, Corn JE

Principal Investigator(s):
Jin Rui (Amos) Liang
2019
PubMed

Insights into ubiquitin chain architecture using Ub-clipping

Swatek KN, Usher JL, Kueck AF, Gladkova C, Mevissen TET, Pruneda JN, Skern T, and Komander D

Principal Investigator(s):
Kirby Swatek
2019
PubMed