Research | Publications

Year

Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System

Simpson LM, Macartney TJ, Nardin A, Fulcher LJ, Röth S, Testa A, Maniaci C, Ciulli A, Ganley IG, Sapkota GP

Principal Investigator(s):
Gopal Sapkota, Ian Ganley
2020
PubMed

Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Bustos F, Segarra-Fas A, Nardocci G, Cassidy A, Antico O, Davidson L, Brandenburg L, Macartney TJ, Toth R, Hastie CJ, Moran J, Gourlay R, Varghese J, Soares RF, Montecino M, Findlay GM

Principal Investigator(s):
Greg Findlay
2020
PubMed

Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal

Mullin NP, Varghese J, Colby D, Richardson JM, Findlay GM, Chambers I

Principal Investigator(s):
Greg Findlay
2020
PubMed
Alt Link

Parkinson’s: A Disease of Aberrant Vesicle Trafficking

Singh, P., K., Muqit M. M.

Principal Investigator(s):
Miratul Muqit
2020
PubMed

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

Tom D Deegan, Pragya P Mukherjee, Ryo Fujisawa, Cristian Polo Rivera, Karim Labib

Principal Investigator(s):
Karim Labib
2020
PubMed
Alt Link

Mechanisms of Activation of Innate-Like Intraepithelial T Lymphocytes

Vandereyken M, James OJ, Swamy M

Principal Investigator(s):
Mahima Swamy
2020
PubMed

Isolation, Characterization, and Culture of Intestinal Intraepithelial Lymphocytes

James, O. J., Vandereyken, M., & Swamy, M

Principal Investigator(s):
Mahima Swamy
2020
PubMed

Comprehensive proteomics analyses identify PIM kinases as key regulators of IL-15 driven activation of intestinal intraepithelial lymphocytes

James OJ, Vandereyken M, Marchingo JM, Singh F, Love AG, Swamy M

Principal Investigator(s):
Mahima Swamy
2020
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Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Fan, Y., Tonelli, F., Padmanabhan, S., Baptista, M., Riley, L., Smith, D., Marras, C., Howden, A., Alessi, D. & Sammler, E.

Principal Investigator(s):
Esther Sammler, Dario Alessi
2020
PubMed

Mitotic kinase anchoring proteins: the navigators of cell division.

Fulcher L, Sapkota GP

Principal Investigator(s):
Gopal Sapkota
2020
PubMed

Characterisation of the biochemical and cellular roles of native and pathogenic amelogenesis imperfecta mutants of FAM83H

Tachie-Menson T, Gázquez-Gutiérrez A, Fulcher LJ, Macartney TJ, Wood NT, Varghese J, Gourlay R, Soares RF, Sapkota GP

Principal Investigator(s):
Gopal Sapkota
2020
PubMed

Expanding the phenotype of the CDKL5 deficiency disorder: Are seizures mandatory?

MacKay CI1, Bick D, Prokop JW, Muñoz I, Rouse J, Downs J, Leonard H.

Principal Investigator(s):
John Rouse
2020
PubMed

A complex comprising C15ORF41 and Codanin-1- the products of two genes mutated in congenital dyserythropoietic anemia type I (CDA-I).

Shroff M, Knebel A, Toth R, Rouse J.

Principal Investigator(s):
John Rouse
2020
PubMed

Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases.

Mathur S, Fletcher AJ, Branigan E, Hay RT, Virdee S.

Principal Investigator(s):
Satpal Virdee
2020
PubMed

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72

Vieweg S, Mulholland K, Brauning B, Kacharia N, Lai YC, Toth R, Singh PK, Volpi I, Sattler M, Groll M, Itzen A, Muqit MMK

Principal Investigator(s):
Miratul Muqit
2020
PubMed

HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation

Zhao, J-F., Rodger, C., Allen, G. F. G., Weidlich, S. & Ganley, I. G

Principal Investigator(s):
Ian Ganley
2020

Semi-automated quantitation of mitophagy in cells and tissues

Montava-Garriga, L., Singh, F., Ball, G. & Ganley, I

Principal Investigator(s):
Ian Ganley
2020
PubMed

The Identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets

Zachari, M., Rainard, J. M., Pandarakalam, G. C., Robinson, L., Gillespie, J., Rajamanickam, M., Hamon, V., Morrison, A., Ganley, I. G. & McElroy, S. P

Principal Investigator(s):
Ian Ganley
2020
PubMed

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses.

Hutchinson, L.D., Darling, N.J., Nicolaou, S, Gori, I., Squair, D., Cohen, P., Hill, C.S. and Sapkota, G.P

Principal Investigator(s):
Gopal Sapkota, Philip Cohen
2020
PubMed

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2

Waschbusch, D., Purlyte, E., Pal, P., McGrath, E., Alessi, D.R., Khan, A.R

Principal Investigator(s):
Dario Alessi
2020
PubMed