Research | Publications

Year

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Ito, G., Katsemonova, K., Tonelli, F., Lis, P., Baptista, M., Shpiro, N., Duddy, G., Wilson, S., Ho, W.L., Ho, S.L., Reith, A.D. and Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2016
PubMed

Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase

Villa, F. Simon, A. C. Ortiz Bazan, M. A. Kilkenny, M. L. Wirthensohn, D. Wightman, M. Matak-Vinkovic, D. Pellegrini, L. Labib, K.

Principal Investigator(s):
Karim Labib
2016
PubMed

Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity

Williams, C. A. Fernandez-Alonso, R. Wang, J. Toth, R. Gray, N. S. Findlay, G. M.

Principal Investigator(s):
Greg Findlay
2016
PubMed

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain

Zhang, J. Gao, G. Begum, G. Wang, J. Khanna, A. R. Shmukler, B. E. Daubner, G. M. de Los Heros, P. Davies, P. Varghese, J. Bhuiyan, M. I. Duan, J. Zhang, J. Duran, D. Alper, S. L. Sun, D. Elledge, S. J. Alessi, D. R. Kahle, K. T.

Principal Investigator(s):
Dario Alessi
2016
PubMed

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M., Cantrell, D. A.

Principal Investigator(s):
Mahima Swamy
2016
PubMed

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R., Mann, M.

Principal Investigator(s):
Dario Alessi
2016
PubMed

Chemical ubiquitination for decrypting a cellular code

Stanley, M., Virdee, S.

Principal Investigator(s):
Satpal Virdee
2016
PubMed

Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation

Pao, K. C., Stanley, M., Han, C., Lai, Y. C., Murphy, P., Balk, K., Wood, N. T., Corti, O., Corvol, J. C., Muqit, M. M., Virdee, S.

Principal Investigator(s):
Miratul Muqit, Satpal Virdee
2016
PubMed

Types of Ubiquitin Ligases

Morreale, F. E., Walden, H.

2016
PubMed

Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice

Lachaud, C., Slean, M., Marchesi, F., Lock, C., Odell, E., Castor, D., Toth, R., Rouse, J.

Principal Investigator(s):
John Rouse
2016
PubMed

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability

Lachaud, C., Moreno, A., Marchesi, F., Toth, R., Blow, J. J., Rouse, J.

Principal Investigator(s):
John Rouse
2016
PubMed

Novel Diubiquitin Probes Expand the Chemical Toolkit to Study DUBs

Kulathu, Y.

Principal Investigator(s):
Yogesh Kulathu
2016
PubMed

ICBS and ECBS Chemical Biology Meeting 2015 - Let Them Come to Berlin!

Komatsu, T., Virdee, S.

Principal Investigator(s):
Satpal Virdee
2016
PubMed

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, D. J., et al inc Ganley, I. G.

Principal Investigator(s):
Ian Ganley
2016
PubMed

Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling

Emmerich, C. H., Bakshi, S., Kelsall, I. R., Ortiz-Guerrero, J., Shpiro, N., Cohen, P.

Principal Investigator(s):
Philip Cohen
2016
PubMed

Specificity and disease in the ubiquitin system

Chaugule, V. K., Walden, H.

2016
PubMed

The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress

Buser, R., Kellner, V., Melnik, A., Wilson-Zbinden, C., Schellhaas, R., Kastner, L., Piwko, W., Dees, M., Picotti, P., Maric, M., Labib, K., Luke, B., Peter, M.

Principal Investigator(s):
Karim Labib
2016
PubMed

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib

Yang, G., Buhrlage, S., Tan, L., Liu, X., Chen, J., Xu, L., Tsakmaklis, N., Chen, J. G., Patterson, C. J., Brown, J. R., Castillo, J. J., Zhang, W., Zhang, X., Liu, S., Cohen, P., Hunter, Z. R., Gray, N., Treon, S. P.

Principal Investigator(s):
Philip Cohen
2016
PubMed

Genetically Directed Production of Recombinant, Isosteric and Non-hydrolyzable Ubiquitin Conjugates

Stanley, M., Virdee, S.

Principal Investigator(s):
Satpal Virdee
2016
PubMed

Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells

King, M. A., Ganley, I. G., Flemington, V.

Principal Investigator(s):
Ian Ganley
2016
PubMed