Protein transformations that change lives

Research | Publications

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

Kumar, A., Aguirre, J. D., Condos, T. E., Martinez-Torres, R. J., Chaugule, V. K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D. E., Barber, K. R., Shaw, G. S., Walden, H.

Principal Investigator(s):

2015

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations

Kristariyanto, Y. A., Choi, S. Y., Rehman, S. A., Ritorto, M. S., Campbell, D. G., Morrice, N. A., Toth, R., Kulathu, Y.

Principal Investigator(s):

2015

K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin

Kristariyanto, Y. A., Abdul Rehman, S. A., Campbell, D. G., Morrice, N. A., Johnson, C., Toth, R., Kulathu, Y.

Principal Investigator(s):

2015

PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

Kazlauskaite, A., Muqit, M. M.

Principal Investigator(s):

2015

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

Kazlauskaite, A., Martinez-Torres, R. J., Wilkie, S., Kumar, A., Peltier, J., Gonzalez, A., Johnson, C., Zhang, J., Hope, A. G., Peggie, M., Trost, M., van Aalten, D. M., Alessi, D. R., Prescott, A. R., Knebel, A., Walden, H., Muqit, M. M.

Principal Investigator(s):

Dario Alessi, Miratul Muqit, Helen Walden

2015

Photoactivatable Prodrugs of Antimelanoma Agent Vemurafenib

Horbert, R., Pinchuk, B., Davies, P., Alessi, D., Peifer, C.

Principal Investigator(s):

2015

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization

Herhaus, L., Perez-Oliva, A. B., Cozza, G., Gourlay, R., Weidlich, S., Campbell, D. G., Pinna, L. A., Sapkota, G. P.

Principal Investigator(s):

2015

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor

Hatcher, J. M., Zhang, J., Choi, H. G., Ito, G., Alessi, D. R., Gray, N. S.

Principal Investigator(s):

2015

A Versatile Strategy for the Semisynthetic Production of Ser65 Phosphorylated Ubiquitin and Its Biochemical and Structural Characterisation

Han, C., Pao, K. C., Kazlauskaite, A., Muqit, M. M., Virdee, S.

Principal Investigator(s):

Miratul Muqit, Satpal Virdee

2015

Structural Characterization of LRRK2 Inhibitors

Gilsbach, B. K., Messias, A. C., Ito, G., Sattler, M., Alessi, D. R., Wittinghofer, A., Kortholt, A.

Principal Investigator(s):

2015

A conserved Pol binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

Garcia-Rodriguez, L. J., De Piccoli, G., Marchesi, V., Jones, R. C., Edmondson, R. D., Labib, K.

Principal Investigator(s):

2015

Optimising methods for the preservation, capture and identification of ubiquitin chains and ubiquitylated proteins by immunoblotting

Emmerich, C. H., Cohen, P.

Principal Investigator(s):

2015

Bill Whelan's impact on my life and career

Cohen, P.

Principal Investigator(s):

2015

Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H., Hay, R. T.

Principal Investigator(s):

2015

The promise and peril of chemical probes

Arrowsmith, C. H. , Audia, J. E., et al including Cohen, P.

Principal Investigator(s):

2015

An important role for A20-binding inhibitor of nuclear factor-kB-1 (ABIN1) in inflammation-mediated endothelial dysfunction: an in vivo study in ABIN1 (D485N) mice

Akbar, N., Nanda, S., Belch, J., Cohen, P., Khan, F.

Principal Investigator(s):

2015

An unexpected twist to the activation of IKKbeta: TAK1 primes IKKbeta for activation by autophosphorylation

Zhang, J., Clark, K., Lawrence, T., Peggie, M. W., Cohen, P.

Principal Investigator(s):

2014

The fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder

Walden, H., Deans, A. J.

Principal Investigator(s):

2014

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

Vogt, J., Dingwell, K. S., Herhaus, L., Gourlay, R., Macartney, T., Campbell, D., Smith, J. C., Sapkota, G. P.

Principal Investigator(s):

2014

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

van der Wijst, J., Blanchard, M. G., Woodroof, H. I., Macartney, T. J., Gourlay, R., Hoenderop, J. G., Bindels, R. J., Alessi, D. R.

Principal Investigator(s):

2014