Research | Publications

Year

RBR E3 ubiquitin ligases: new structures, new insights, new questions

Spratt, D. E., Walden, H., Shaw, G. S.

Principal Investigator(s):
Helen Walden
2014
PubMed

A Ctf4 trimer couples the CMG helicase to DNA polymerase alpha in the eukaryotic replisome

Simon, A. C., Zhou, J. C., Perera, R. L., van Deursen, F., Evrin, C., Ivanova, M. E., Kilkenny, M. L., Renault, L., Kjaer, S., Matak-Vinkovic, D., Labib, K., Costa, A., Pellegrini, L.

Principal Investigator(s):
Karim Labib
2014
PubMed

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

Schumacher, F. R., Sorrell, F. J., Alessi, D. R., Bullock, A. N., Kurz, T.

Principal Investigator(s):
Dario Alessi
2014
PubMed

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Schonhuber, N., Seidler, B., Schuck, K., Veltkamp, C., Schachtler, C., Zukowska, M., Eser, S., Feyerabend, T. B., Paul, M. C., Eser, P., Klein, S., Lowy, A. M., Banerjee, R., Yang, F., Lee, C. L., Moding, E. J., Kirsch, D. G., Scheideler, A., Alessi, D. R., Varela, I., Bradl

Principal Investigator(s):
Dario Alessi
2014
PubMed

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., Gray, N. S., Morrice, N. A., Alessi, D. R., Trost, M.

Principal Investigator(s):
Dario Alessi, Satpal Virdee
2014
PubMed

FAN1 Activity on Asymmetric Repair Intermediates Is Mediated by an Atypical Monomeric Virus-type Replication-Repair Nuclease Domain

Pennell, S., Declais, A. C., Li, J., Haire, L. F., Berg, W., Saldanha, J. W., Taylor, I. A., Rouse, J., Lilley, D. M., Smerdon, S. J.

Principal Investigator(s):
John Rouse
2014
PubMed

Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein

Nair, N., Castor, D., Macartney, T., Rouse, J.

Principal Investigator(s):
John Rouse
2014
PubMed

Improved Genome Editing in Human Cell Lines Using the CRISPR Method

Munoz, I. M., Szyniarowski, P., Toth, R., Rouse, J., Lachaud, C.

Principal Investigator(s):
John Rouse
2014
PubMed

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

Maric, M., Maculins, T., De Piccoli, G., Labib, K.

Principal Investigator(s):
Karim Labib
2014
PubMed

Protein kinase IKKbeta-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

Lopez-Pelaez, M., Lamont, D. J., Peggie, M., Shpiro, N., Gray, N. S., Cohen, P.

Principal Investigator(s):
Philip Cohen
2014
PubMed

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

Lin, K. M., Hu, W., Troutman, T. D., Jennings, M., Brewer, T., Li, X., Nanda, S., Cohen, P., Thomas, J. A., Pasare, C.

Principal Investigator(s):
Philip Cohen
2014
PubMed

Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia

Lachaud, C., Castor, D., Hain, K., Munoz, I., Wilson, J., MacArtney, T. J., Schindler, D., Rouse, J.

Principal Investigator(s):
John Rouse
2014
PubMed

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M., Muqit, M. M.

Principal Investigator(s):
Dario Alessi, Miratul Muqit
2014
PubMed

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

Kazlauskaite, A., Kelly, V., Johnson, C., Baillie, C., Hastie, C. J., Peggie, M., Macartney, T., Woodroof, H. I., Alessi, D. R., Pedrioli, P. G., Muqit, M. M.

Principal Investigator(s):
Dario Alessi, Miratul Muqit
2014
PubMed

The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons

Iovino, M., Pfisterer, U., Holton, J. L., Lashley, T., Swingler, R. J., Calo, L., Treacy, R., Revesz, T., Parmar, M., Goedert, M., Muqit, M. M., Spillantini, M. G.

Principal Investigator(s):
Miratul Muqit
2014
PubMed

Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Houde, V. P., Ritorto, M. S., Gourlay, R., Varghese, J., Davies, P., Shpiro, N., Sakamoto, K., Alessi, D. R.

Principal Investigator(s):
Dario Alessi
2014
PubMed

Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection

Hodson, C., Purkiss, A., Miles, J. A., Walden, H.

Principal Investigator(s):
Helen Walden
2014
PubMed

The emerging roles of deubiquitylating enzymes (DUBs) in the TGFbeta and BMP pathways

Herhaus, L., Sapkota, G. P.

Principal Investigator(s):
Gopal Sapkota
2014
PubMed

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling

Herhaus, L., Al-Salihi, M. A., Dingwell, K. S., Cummins, T. D., Wasmus, L., Vogt, J., Ewan, R., Bruce, D., Macartney, T., Weidlich, S., Smith, J. C., Sapkota, G. P.

Principal Investigator(s):
Gopal Sapkota
2014
PubMed

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

de Los Heros, P., Alessi, D. R., Gourlay, R., Campbell, D. G., Deak, M., Macartney, T. J., Kahle, K. T., Zhang, J.

Principal Investigator(s):
Dario Alessi
2014
PubMed