Protein transformations that change lives

Research | Publications

Immune diseases caused by mutations in kinases and components of the ubiquitin system

Cohen, P.

Principal Investigator(s):

2014

The TLR and IL-1 signalling network at a glance

Cohen, P.

Principal Investigator(s):

2014

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1betaMYPT1 phosphatase complex and the SCFbetaTrCP E3 ubiquitin ligase

Banerjee, S., Zagorska, A., Deak, M., Campbell, D. G., Prescott, A. R., Alessi, D. R.

Principal Investigator(s):

2014

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

Banerjee, S., Buhrlage, S. J., Huang, H. T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A. R., Alessi, D. R., Gray, N. S.

Principal Investigator(s):

2014

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G., Alessi, D. R.

Principal Investigator(s):

Dario Alessi, Ian Ganley

2014

The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

Alessi, D. R., Zhang, J., Khanna, A., Hochdorfer, T., Shang, Y., Kahle, K. T.

Principal Investigator(s):

2014

Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation

Yasui, N., Findlay, G. M., Gish, G. D., Hsiung, M. S., Huang, J., Tucholska, M., Taylor, L., Smith, L., Boldridge, W. C., Koide, A., Pawson, T., Koide, S.

Principal Investigator(s):

2014

A quantitative liposome microarray to systematically characterize protein-lipid interactions

Saliba, A. E., Vonkova, I., Ceschia, S., Findlay, G. M., Maeda, K., Tischer, C., Deghou, S., van Noort, V., Bork, P., Pawson, T., Ellenberg, J., Gavin, A. C.

Principal Investigator(s):

2014

The binding properties of the Sos1/Grb2 complex define timing and selectivity in stem cell lineage commitment.

Findlay, G.M., Smith, M.J., Lanner, F., Hsiung, M.S., Gish, G.D., Petsalaki, E., Kaneko, T., Huang, H., Bagshaw, R.D., Ketela, T., Tucholska, M., Taylor, L., Bowtell, D.D., Moffat, J., Ikura, M., Li, S.C., Sidhu, S.S., Rossant, J. and Pawson, T.

Principal Investigator(s):

2013

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

Yao, C., Johnson, W. M., Gao, Y., Wang, W., Zhang, J., Deak, M., Alessi, D. R., Zhu, X., Mieyal, J. J., Roder, H., Wilson-Delfosse, A. L., Chen, S. G.

Principal Investigator(s):

2013

The ULK1 complex: Sensing nutrient signals for autophagy activation

Wong, P. M., Puente, C., Ganley, I. G., Jiang, X.

Principal Investigator(s):

2013

Localization-dependent and -independent roles of SLX4 in regulating telomeres

Wilson, J. S., Tejera, A. M., Castor, D., Toth, R., Blasco, M. A., Rouse, J.

Principal Investigator(s):

2013

PKB/SGK-Resistant GSK-3 Signaling Following Unilateral Ureteral Obstruction

Voelkl, J., Mia, S., Meissner, A., Ahmed, M. S., Feger, M., Elvira, B., Walker, B., Alessi, D. R., Alesutan, I., Lang, F.

Principal Investigator(s):

2013

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N., Cohen, P.

Principal Investigator(s):

2013

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Sommer, E. M., Dry, H., Cross, D., Guichard, S., Davies, B. R., Alessi, D. R.

Principal Investigator(s):

2013

The TGFbeta-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1

Sapkota, G. P.

Principal Investigator(s):

2013

Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice

Pauls, E., Nanda, S. K., Smith, H., Toth, R., Arthur, J. S., Cohen, P.

Principal Investigator(s):

2013

DEAF1 Is a Pellino1-interacting Protein Required for Interferon Production by Sendai Virus and Double-stranded RNA

Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R., Cohen, P.

Principal Investigator(s):

2013

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Ohta, A., Schumacher, F. R., Mehellou, Y., Johnson, C., Knebel, A., Macartney, T. J., Wood, N. T., Alessi, D. R., Kurz, T.

Principal Investigator(s):

2013

N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling

Melo, Z., de los Heros, P., Cruz-Rangel, S., Vazquez, N., Bobadilla, N. A., Pasantes-Morales, H., Alessi, D. R., Mercado, A., Gamba, G.

Principal Investigator(s):

2013