Research | Publications

Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases.

Gomez, RC, Wawro, P, Lis, P, Alessi, D & Pfeffer, SR

Principal Investigator(s):
Dario Alessi
2019
PubMed

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication.

Sonneville, R, Bhowmick, R, Hoffmann, S, Mailand, N, Hickson, ID & Labib, K

Principal Investigator(s):
Karim Labib
2019
PubMed

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44.

Malik, N, Nirujogi, RS, Peltier, J, Macartney, T, Wightman, M, Prescott, A, Gourlay, R, Trost, M, Alessi, D & Karapetsas, A

Principal Investigator(s):
Dario Alessi
2019
PubMed

Ways to unwind with HROB, a new player in homologous recombination.

Saredi, G & Rouse, J

Principal Investigator(s):
John Rouse
2019
PubMed

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

Berndsen, K, Lis, P, Yeshaw, WM, Wawro, PS, Nirujogi, R, Wightman, M, Macartney, T, Dorward, M, Knebel, A, Tonelli, F, Pfeffer, SR & Alessi, D

Principal Investigator(s):
Dario Alessi
2019
PubMed

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, TG, Prescott, A, Villarejo-Zori, B, Ball, G, Boya, P & Ganley,

Principal Investigator(s):
Ian Ganley
2019
PubMed

Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes

Deegan, T, Baxter, J, Ortiz Bazan, M, Yeeles, JTP & Labib, K

Principal Investigator(s):
Karim Labib
2019
PubMed

Crystal structure of the WD40 domain dimer of LRRK2

Zhang, P, Fan, Y, Ru, H, Wang, L, Magupalli, VG, Taylor, SS, Alessi, DR & Wu, H

Principal Investigator(s):
Dario Alessi
2019
PubMed

Investigating Mitophagy and Mitochondrial Morphology In Vivo Using mito-QC: A Comprehensive Guide

McWilliams, TG & Ganley, IG

Principal Investigator(s):
Ian Ganley
2019
PubMed

'Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling

Kelsall, IR, Kristariyanto, YA, Knebel, A, Wood, NT, Kulathu, Y & Alpi, AF

Principal Investigator(s):
Yogesh Kulathu
2019
PubMed

Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1a association and attenuate Wnt signalling

Kevin Z L Wu, Rebecca A Jones, Theresa Tachie-Menson, Thomas J Macartney, Nicola T Wood, Joby Varghese, Robert Gourlay, Renata F Soares, James C Smith and Gopal P Sapkota

Principal Investigator(s):
Gopal Sapkota
2019

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Yu Chen, Maud Vandereyken, Ian P. Newton, Ignacio Moraga, Inke S. Näthke, Mahima Swamy

Principal Investigator(s):
Mahima Swamy
2019
PubMed

Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice

Nanda, S. K., Petrova, T., Marchesi, F., Gierlinski, M., Razsolkov, M., Lee, K. L., Wright, S. W., Rao, V. R., Cohen, P. and Arthur, J. S. C.

Principal Investigator(s):
Philip Cohen
2019
PubMed

The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells

Kelsall, I. R., Zhang, J., Knebel, A., Arthur, J. S. C. and Cohen, P

Principal Investigator(s):
Philip Cohen
2019
PubMed

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning.

Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R. G., Campbell, D. G., Maxwell, C. A., and Sapkota G. P.

Principal Investigator(s):
Gopal Sapkota
2019
PubMed

Ubiquitin-mediated regulation of RIPK1 kinase activity, independent of IKK and MK2

Annibaldi A, John SW*, Berghe TV*, Swatek KN*, Ruan J, Wu H, Liccardi G, Bianchi K, Komander D, Choi SM, Coille SV, Vandenabeele P, Bertin J, Silke J, and Meier P

Principal Investigator(s):
Kirby Swatek
2018
PubMed

A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation

Pruneda JN, Bastidas RJ, Bertsoulaki E, Swatek KN, Santhanam B, Clauge MJ, Valdivia RH, Urbe S, and Komander D

Principal Investigator(s):
Kirby Swatek
2018
PubMed

Cancer-Associated PIK3CA Mutations in Overgrowth Disorders.

Madsen, R. R., Vanhaesebroeck, B. & Semple, R. K.

Principal Investigator(s):
Ralitsa Madsen
2018
PubMed

Atlastins remodel the endoplasmic reticulum for selective autophagy. Journal of Cell Biology

Liang JR, Lingeman E, Ahmed S, Corn JE

Principal Investigator(s):
Jin Rui (Amos) Liang
2018
PubMed

Phosphoproteomic screening identifies cytoskeleton regulators as novel targets of the CDKL5 kinase

Muñoz, I., Morgan, M., Peltier, J., Weiland, F., Gregorczyk, M., Macartney, T.J., Brown, F., Toth, R., Trost, M. and Rouse, J.

Principal Investigator(s):
John Rouse
2018
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